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The effect of metronidazole on Bacteroides fragilis and Escherichia coli
The antibiotic metronidazole is used extensively in the clinical treatment of anaerobic infections, including those caused by the anaerobic pathogen Bacteroides fragilis. Metronidazole is an inert substance that requires reductive activation to become cytotoxic. In its activated form metronidazole i...
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| Format: | Thesis |
| Language: | English |
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Department of Molecular and Cell Biology
2016
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| _version_ | 1867613344171556864 |
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| access_status_str | Open Access |
| author | Dachs, Gabriele Ursula |
| author2 | Abratt, Valerie Rose |
| author_browse | Abratt, Valerie Rose Dachs, Gabriele Ursula |
| author_facet | Abratt, Valerie Rose Dachs, Gabriele Ursula |
| author_sort | Dachs, Gabriele Ursula |
| collection | Thesis |
| description | The antibiotic metronidazole is used extensively in the clinical treatment of anaerobic infections, including those caused by the anaerobic pathogen Bacteroides fragilis. Metronidazole is an inert substance that requires reductive activation to become cytotoxic. In its activated form metronidazole induces DNA damage. Relatively little is known about the cytotoxic effects of this drug in vivo. The aim of the work reported in this thesis was to analyze the mode of action of metronidazole in living systems. Furthermore, the potential for bacterial cells to develop resistance mechanisms to metronidazole is largely unknown, and therefore the role played by B. fragilis genes in influencing the potency of metronidazole was investigated.
Bibliography: pages 172-201. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/18281 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:39.078Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Department of Molecular and Cell Biology |
| publisherStr | Department of Molecular and Cell Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/18281 The effect of metronidazole on Bacteroides fragilis and Escherichia coli Dachs, Gabriele Ursula Abratt, Valerie Rose Woods, David R Molecular and Cell Biology The antibiotic metronidazole is used extensively in the clinical treatment of anaerobic infections, including those caused by the anaerobic pathogen Bacteroides fragilis. Metronidazole is an inert substance that requires reductive activation to become cytotoxic. In its activated form metronidazole induces DNA damage. Relatively little is known about the cytotoxic effects of this drug in vivo. The aim of the work reported in this thesis was to analyze the mode of action of metronidazole in living systems. Furthermore, the potential for bacterial cells to develop resistance mechanisms to metronidazole is largely unknown, and therefore the role played by B. fragilis genes in influencing the potency of metronidazole was investigated. Bibliography: pages 172-201. 2016-03-28T14:33:32Z 2016-03-28T14:33:32Z 1992 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/18281 eng application/pdf Department of Molecular and Cell Biology Faculty of Science University of Cape Town |
| spellingShingle | Molecular and Cell Biology Dachs, Gabriele Ursula The effect of metronidazole on Bacteroides fragilis and Escherichia coli |
| thesis_degree_str | Doctoral |
| title | The effect of metronidazole on Bacteroides fragilis and Escherichia coli |
| title_full | The effect of metronidazole on Bacteroides fragilis and Escherichia coli |
| title_fullStr | The effect of metronidazole on Bacteroides fragilis and Escherichia coli |
| title_full_unstemmed | The effect of metronidazole on Bacteroides fragilis and Escherichia coli |
| title_short | The effect of metronidazole on Bacteroides fragilis and Escherichia coli |
| title_sort | effect of metronidazole on bacteroides fragilis and escherichia coli |
| topic | Molecular and Cell Biology |
| url | http://hdl.handle.net/11427/18281 |
| work_keys_str_mv | AT dachsgabrieleursula theeffectofmetronidazoleonbacteroidesfragilisandescherichiacoli AT dachsgabrieleursula effectofmetronidazoleonbacteroidesfragilisandescherichiacoli |