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Development, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexes
Over the past few decades metals in medicine have played to play a significant role, especially after the discovery of the anticancer properties of cisplatin. However, acquired and intrinsic resistance, toxicity and a host of side-effects have encouraged the research for new metal based anticancer a...
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| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2016
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| _version_ | 1867613250249555968 |
|---|---|
| access_status_str | Open Access |
| author | Burgoyne, Andrew R |
| author2 | Smith, Gregory S |
| author_browse | Burgoyne, Andrew R Smith, Gregory S |
| author_facet | Smith, Gregory S Burgoyne, Andrew R |
| author_sort | Burgoyne, Andrew R |
| collection | Thesis |
| description | Over the past few decades metals in medicine have played to play a significant role, especially after the discovery of the anticancer properties of cisplatin. However, acquired and intrinsic resistance, toxicity and a host of side-effects have encouraged the research for new metal based anticancer agents. Organometallic complexes have proved to be successful anticancer agents and several have commenced clinical trials. The aim of this study was to prepare and characterize trinuclear platinum group organometallic complexes and investigate their in vitro activity. The first series of ester containing complexes were prepared. The ligands were generated by the preparation of Schiff base ligands obtained from the condensation of 4-aminophenylmethanol and either benzaldehyde, 2-pyridinecarboxaldehyde or salicylaldehyde. Trimeric ester ligands were prepared from these monomeric ligands by reaction with trimesoyl chloride. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/20303 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:08.525Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/20303 Development, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexes Burgoyne, Andrew R Smith, Gregory S Chemistry Over the past few decades metals in medicine have played to play a significant role, especially after the discovery of the anticancer properties of cisplatin. However, acquired and intrinsic resistance, toxicity and a host of side-effects have encouraged the research for new metal based anticancer agents. Organometallic complexes have proved to be successful anticancer agents and several have commenced clinical trials. The aim of this study was to prepare and characterize trinuclear platinum group organometallic complexes and investigate their in vitro activity. The first series of ester containing complexes were prepared. The ligands were generated by the preparation of Schiff base ligands obtained from the condensation of 4-aminophenylmethanol and either benzaldehyde, 2-pyridinecarboxaldehyde or salicylaldehyde. Trimeric ester ligands were prepared from these monomeric ligands by reaction with trimesoyl chloride. 2016-07-11T13:53:39Z 2016-07-11T13:53:39Z 2016 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/20303 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Burgoyne, Andrew R Development, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexes |
| thesis_degree_str | Doctoral |
| title | Development, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexes |
| title_full | Development, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexes |
| title_fullStr | Development, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexes |
| title_full_unstemmed | Development, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexes |
| title_short | Development, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexes |
| title_sort | development synthesis and anticancer evaluation of trinuclear platinum group metal organometallic complexes |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/20303 |
| work_keys_str_mv | AT burgoyneandrewr developmentsynthesisandanticancerevaluationoftrinuclearplatinumgroupmetalorganometalliccomplexes |