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Magnesium recurarisation differences between no reversal, neostigmine/glycopyrrolate reversal and sugammadex reversal of neuromuscular block in an in vivo rat model
The neuromuscular junction (NMJ) is a synapse with one of the highest safety margins in the human body. The use of neuromuscular blocking agents to inhibit neuromuscular transmission is sufficient to produce skeletal muscle paralysis, a mechanism used to facilitate muscle relaxation during surgery....
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| Format: | Thesis |
| Language: | English |
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Department of Human Biology
2016
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| _version_ | 1867613170847186944 |
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| access_status_str | Open Access |
| author | Van den Berg, Maurits Matthew |
| author2 | Kellaway, Lauriston A |
| author_browse | Kellaway, Lauriston A Van den Berg, Maurits Matthew |
| author_facet | Kellaway, Lauriston A Van den Berg, Maurits Matthew |
| author_sort | Van den Berg, Maurits Matthew |
| collection | Thesis |
| description | The neuromuscular junction (NMJ) is a synapse with one of the highest safety margins in the human body. The use of neuromuscular blocking agents to inhibit neuromuscular transmission is sufficient to produce skeletal muscle paralysis, a mechanism used to facilitate muscle relaxation during surgery. Residual neuromuscular block postoperatively has been found to be a major risk factor for postoperative complications. Sudden reinstatement of neuromuscular block (recurarisation), through use of magnesium, has also been observed clinically. This has led to a reluctance to use magnesium postoperatively for fear of recurarisation. Recurarisation following reversal of neuromuscular blockade with neostigmine or sugammadex has not been evaluated in a formal study, and for this reason, this study investigated recurarisation after 30 mg/kg magnesium sulphate (MgSO4) following reversal of neuromuscular blockade with neostigmine, two dosages of sugammadex or when reversal was omitted. Prior to investigating recurarisation, the effects of magnesium on neuromuscular transmission in the absence of neuromuscular blocking agents was investigated, in order to determine a standard clinical dose that did not produce detectable, by Train-of-Four Ratio (TOF-R) or Twitch 1 height (%T1), neuromuscular impairment. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/20493 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:53.390Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Department of Human Biology |
| publisherStr | Department of Human Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/20493 Magnesium recurarisation differences between no reversal, neostigmine/glycopyrrolate reversal and sugammadex reversal of neuromuscular block in an in vivo rat model Van den Berg, Maurits Matthew Kellaway, Lauriston A James, Michael F Swanevelder, Justiaan Neuroscience The neuromuscular junction (NMJ) is a synapse with one of the highest safety margins in the human body. The use of neuromuscular blocking agents to inhibit neuromuscular transmission is sufficient to produce skeletal muscle paralysis, a mechanism used to facilitate muscle relaxation during surgery. Residual neuromuscular block postoperatively has been found to be a major risk factor for postoperative complications. Sudden reinstatement of neuromuscular block (recurarisation), through use of magnesium, has also been observed clinically. This has led to a reluctance to use magnesium postoperatively for fear of recurarisation. Recurarisation following reversal of neuromuscular blockade with neostigmine or sugammadex has not been evaluated in a formal study, and for this reason, this study investigated recurarisation after 30 mg/kg magnesium sulphate (MgSO4) following reversal of neuromuscular blockade with neostigmine, two dosages of sugammadex or when reversal was omitted. Prior to investigating recurarisation, the effects of magnesium on neuromuscular transmission in the absence of neuromuscular blocking agents was investigated, in order to determine a standard clinical dose that did not produce detectable, by Train-of-Four Ratio (TOF-R) or Twitch 1 height (%T1), neuromuscular impairment. 2016-07-20T06:58:41Z 2016-07-20T06:58:41Z 2016 Master Thesis Masters MSc (Med) http://hdl.handle.net/11427/20493 eng application/pdf Department of Human Biology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Neuroscience Van den Berg, Maurits Matthew Magnesium recurarisation differences between no reversal, neostigmine/glycopyrrolate reversal and sugammadex reversal of neuromuscular block in an in vivo rat model |
| thesis_degree_str | Master's |
| title | Magnesium recurarisation differences between no reversal, neostigmine/glycopyrrolate reversal and sugammadex reversal of neuromuscular block in an in vivo rat model |
| title_full | Magnesium recurarisation differences between no reversal, neostigmine/glycopyrrolate reversal and sugammadex reversal of neuromuscular block in an in vivo rat model |
| title_fullStr | Magnesium recurarisation differences between no reversal, neostigmine/glycopyrrolate reversal and sugammadex reversal of neuromuscular block in an in vivo rat model |
| title_full_unstemmed | Magnesium recurarisation differences between no reversal, neostigmine/glycopyrrolate reversal and sugammadex reversal of neuromuscular block in an in vivo rat model |
| title_short | Magnesium recurarisation differences between no reversal, neostigmine/glycopyrrolate reversal and sugammadex reversal of neuromuscular block in an in vivo rat model |
| title_sort | magnesium recurarisation differences between no reversal neostigmine glycopyrrolate reversal and sugammadex reversal of neuromuscular block in an in vivo rat model |
| topic | Neuroscience |
| url | http://hdl.handle.net/11427/20493 |
| work_keys_str_mv | AT vandenbergmauritsmatthew magnesiumrecurarisationdifferencesbetweennoreversalneostigmineglycopyrrolatereversalandsugammadexreversalofneuromuscularblockinaninvivoratmodel |