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Computational biomechanics in the remodelling rat heart post myocardial infarction
Cardiovascular diseases account for one third of all deaths worldwide, more than 33% of which are related to ischemic heart disease, including myocardial infarction (MI). This thesis seeks to provide insight and understanding of mechanisms during different stages of MI by utilizing finite element (F...
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| Format: | Thesis |
| Language: | English |
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Division of Cardiology
2016
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| _version_ | 1867613244781232128 |
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| access_status_str | Open Access |
| author | Masithulela, Fulufhelo James |
| author2 | Franz , Thomas |
| author_browse | Franz , Thomas Masithulela, Fulufhelo James |
| author_facet | Franz , Thomas Masithulela, Fulufhelo James |
| author_sort | Masithulela, Fulufhelo James |
| collection | Thesis |
| description | Cardiovascular diseases account for one third of all deaths worldwide, more than 33% of which are related to ischemic heart disease, including myocardial infarction (MI). This thesis seeks to provide insight and understanding of mechanisms during different stages of MI by utilizing finite element (FE) modelling. Three-dimensional biventricular rat heart geometries were developed from cardiac magnetic resonance images of a healthy heart and a heart with left ventricular (LV) infarction two weeks and four weeks after infarct induction. From these geometries, FE models were established. To represent the myocardium, a structure-based constitutive model and a rule-based myofibre distribution were developed to simulate both passive mechanics and active contraction. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/20555 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:04.194Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Division of Cardiology |
| publisherStr | Division of Cardiology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/20555 Computational biomechanics in the remodelling rat heart post myocardial infarction Masithulela, Fulufhelo James Franz , Thomas Davies, Neil Dubuis, Laura Cardiovascular Biomechanics Cardiovascular diseases account for one third of all deaths worldwide, more than 33% of which are related to ischemic heart disease, including myocardial infarction (MI). This thesis seeks to provide insight and understanding of mechanisms during different stages of MI by utilizing finite element (FE) modelling. Three-dimensional biventricular rat heart geometries were developed from cardiac magnetic resonance images of a healthy heart and a heart with left ventricular (LV) infarction two weeks and four weeks after infarct induction. From these geometries, FE models were established. To represent the myocardium, a structure-based constitutive model and a rule-based myofibre distribution were developed to simulate both passive mechanics and active contraction. 2016-07-21T11:01:14Z 2016-07-21T11:01:14Z 2016 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/20555 eng application/pdf Division of Cardiology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Cardiovascular Biomechanics Masithulela, Fulufhelo James Computational biomechanics in the remodelling rat heart post myocardial infarction |
| thesis_degree_str | Doctoral |
| title | Computational biomechanics in the remodelling rat heart post myocardial infarction |
| title_full | Computational biomechanics in the remodelling rat heart post myocardial infarction |
| title_fullStr | Computational biomechanics in the remodelling rat heart post myocardial infarction |
| title_full_unstemmed | Computational biomechanics in the remodelling rat heart post myocardial infarction |
| title_short | Computational biomechanics in the remodelling rat heart post myocardial infarction |
| title_sort | computational biomechanics in the remodelling rat heart post myocardial infarction |
| topic | Cardiovascular Biomechanics |
| url | http://hdl.handle.net/11427/20555 |
| work_keys_str_mv | AT masithulelafulufhelojames computationalbiomechanicsintheremodellingratheartpostmyocardialinfarction |