Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study
Streptococcus pneumoniae (the pneumococcus) is the most common cause of childhood pneumonia. Nasopharyngeal (NP) colonization by the pneumococcus is a necessary first step in the pathogenesis of pneumonia and yet the dynamic nature of pneumococcal colonization remains incompletely understood. In chi...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Medical Biochemistry
2016
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613267199787009 |
|---|---|
| access_status_str | Open Access |
| author | Dube, Felix Sizwe |
| author2 | Mulder, Nicola |
| author_browse | Dube, Felix Sizwe Mulder, Nicola |
| author_facet | Mulder, Nicola Dube, Felix Sizwe |
| author_sort | Dube, Felix Sizwe |
| collection | Thesis |
| description | Streptococcus pneumoniae (the pneumococcus) is the most common cause of childhood pneumonia. Nasopharyngeal (NP) colonization by the pneumococcus is a necessary first step in the pathogenesis of pneumonia and yet the dynamic nature of pneumococcal colonization remains incompletely understood. In children, asymptomatic colonization of the nasopharynx by the pneumococcus is common and also serves as a reservoir for person-to-person transmission. We aimed to investigate in detail, the dynamics of pneumococcal nasopharyngeal carriage over the first year of life, in a cohort of South African children, particularly after implementation of the 13-valent pneumococcal conjugate vaccine (PCV-13). The study will further elucidate the interaction of S. pneumoniae with other respiratory pathogens and how such interactions may contribute development of severe disease. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/20649 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:25.185Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Division of Medical Biochemistry |
| publisherStr | Division of Medical Biochemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/20649 Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study Dube, Felix Sizwe Mulder, Nicola Kaba, Mamadou Medical Microbiology Streptococcus pneumoniae (the pneumococcus) is the most common cause of childhood pneumonia. Nasopharyngeal (NP) colonization by the pneumococcus is a necessary first step in the pathogenesis of pneumonia and yet the dynamic nature of pneumococcal colonization remains incompletely understood. In children, asymptomatic colonization of the nasopharynx by the pneumococcus is common and also serves as a reservoir for person-to-person transmission. We aimed to investigate in detail, the dynamics of pneumococcal nasopharyngeal carriage over the first year of life, in a cohort of South African children, particularly after implementation of the 13-valent pneumococcal conjugate vaccine (PCV-13). The study will further elucidate the interaction of S. pneumoniae with other respiratory pathogens and how such interactions may contribute development of severe disease. 2016-07-25T07:12:35Z 2016-07-25T07:12:35Z 2016 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/20649 eng application/pdf Division of Medical Biochemistry Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Microbiology Dube, Felix Sizwe Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study |
| thesis_degree_str | Doctoral |
| title | Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study |
| title_full | Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study |
| title_fullStr | Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study |
| title_full_unstemmed | Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study |
| title_short | Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study |
| title_sort | longitudinal colonisation by streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease a south african birth cohort study |
| topic | Medical Microbiology |
| url | http://hdl.handle.net/11427/20649 |
| work_keys_str_mv | AT dubefelixsizwe longitudinalcolonisationbystreptococcuspneumoniaeandnasopharyngealmicrobialinteractionsinhealthanddiseaseasouthafricanbirthcohortstudy |