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Dental implications of inherited connective tissue disorders in South Africa
The prevalence of Osteogenesis imperfecta type III (OI III) as a category of the inherited connective tissue disorders in South Africa is of paramount importance. Although worldwide, autosomal recessive(AR) OI is rare, it had emerged that the frequency of OI III is relatively high in the indigenous...
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| Format: | Thesis |
| Language: | English |
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Division of Human Genetics
2016
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| _version_ | 1867613267200835584 |
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| access_status_str | Open Access |
| author | Chetty, Manogari |
| author2 | Beighton, Peter |
| author_browse | Beighton, Peter Chetty, Manogari |
| author_facet | Beighton, Peter Chetty, Manogari |
| author_sort | Chetty, Manogari |
| collection | Thesis |
| description | The prevalence of Osteogenesis imperfecta type III (OI III) as a category of the inherited connective tissue disorders in South Africa is of paramount importance. Although worldwide, autosomal recessive(AR) OI is rare, it had emerged that the frequency of OI III is relatively high in the indigenous Black African population of South Africa. A review of the literature revealed a paucity of information regarding the dental and craniofacial manifestations of the disorder in this ethnic group. For these reasons, the central theme of this thesis is the identification, documentation and analysis of these features in individuals with OI III in the Black African population of SA. Osteogenesis imperfecta type III (OMIM 259420) is a severe autosomal recessive disorder in which frequent fractures and progressive limb and spinal deformity result in profound physical disability. The condition is heterogeneous and dentin genesis imperfecta (DI) is an important syndromic component of some types of OI III. Other maxillofacial and dental manifestations also have significant implications in terms of management. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/20851 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:25.185Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Division of Human Genetics |
| publisherStr | Division of Human Genetics |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/20851 Dental implications of inherited connective tissue disorders in South Africa Chetty, Manogari Beighton, Peter Stephen, Lawrence X G Oral Medicine and Periodontics The prevalence of Osteogenesis imperfecta type III (OI III) as a category of the inherited connective tissue disorders in South Africa is of paramount importance. Although worldwide, autosomal recessive(AR) OI is rare, it had emerged that the frequency of OI III is relatively high in the indigenous Black African population of South Africa. A review of the literature revealed a paucity of information regarding the dental and craniofacial manifestations of the disorder in this ethnic group. For these reasons, the central theme of this thesis is the identification, documentation and analysis of these features in individuals with OI III in the Black African population of SA. Osteogenesis imperfecta type III (OMIM 259420) is a severe autosomal recessive disorder in which frequent fractures and progressive limb and spinal deformity result in profound physical disability. The condition is heterogeneous and dentin genesis imperfecta (DI) is an important syndromic component of some types of OI III. Other maxillofacial and dental manifestations also have significant implications in terms of management. 2016-07-27T10:21:15Z 2016-07-27T10:21:15Z 2016 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/20851 eng application/pdf Division of Human Genetics Faculty of Health Sciences University of Cape Town |
| spellingShingle | Oral Medicine and Periodontics Chetty, Manogari Dental implications of inherited connective tissue disorders in South Africa |
| thesis_degree_str | Doctoral |
| title | Dental implications of inherited connective tissue disorders in South Africa |
| title_full | Dental implications of inherited connective tissue disorders in South Africa |
| title_fullStr | Dental implications of inherited connective tissue disorders in South Africa |
| title_full_unstemmed | Dental implications of inherited connective tissue disorders in South Africa |
| title_short | Dental implications of inherited connective tissue disorders in South Africa |
| title_sort | dental implications of inherited connective tissue disorders in south africa |
| topic | Oral Medicine and Periodontics |
| url | http://hdl.handle.net/11427/20851 |
| work_keys_str_mv | AT chettymanogari dentalimplicationsofinheritedconnectivetissuedisordersinsouthafrica |