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Investigating the Influence of Methamphetamine on brain metabolism using 1H-MRS
Methamphetamine (MA) has been shown to have a detrimental relationship with on neuronal integrity and viability, and has been associated with decreased executive function. The association of acute and short-term MA abstinence on brain metabolism, in adult MA abusers, is understudied. Negative relati...
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Psychiatry and Mental Health
2016
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| _version_ | 1867613991417675776 |
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| access_status_str | Open Access |
| author | Burger, Antoinette |
| author2 | Howells, Fleur M |
| author_browse | Burger, Antoinette Howells, Fleur M |
| author_facet | Howells, Fleur M Burger, Antoinette |
| author_sort | Burger, Antoinette |
| collection | Thesis |
| description | Methamphetamine (MA) has been shown to have a detrimental relationship with on neuronal integrity and viability, and has been associated with decreased executive function. The association of acute and short-term MA abstinence on brain metabolism, in adult MA abusers, is understudied. Negative relationships with brain metabolism, cognitive development and executive functioning in prenatally MA exposed children are reported, however these studies are limited. The aim of this study was to investigate the relationship between MA and brain metabolism in adults after acute and short-term abstinence. An additional aim was to investigate neurometabolite changes and relationship with general cognitive ability over time in prenatally MA exposed children. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/21000 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:44:56.576Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Department of Psychiatry and Mental Health |
| publisherStr | Department of Psychiatry and Mental Health |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/21000 Investigating the Influence of Methamphetamine on brain metabolism using 1H-MRS Burger, Antoinette Howells, Fleur M Stein, Dan J Neuroscience Methamphetamine (MA) has been shown to have a detrimental relationship with on neuronal integrity and viability, and has been associated with decreased executive function. The association of acute and short-term MA abstinence on brain metabolism, in adult MA abusers, is understudied. Negative relationships with brain metabolism, cognitive development and executive functioning in prenatally MA exposed children are reported, however these studies are limited. The aim of this study was to investigate the relationship between MA and brain metabolism in adults after acute and short-term abstinence. An additional aim was to investigate neurometabolite changes and relationship with general cognitive ability over time in prenatally MA exposed children. 2016-07-28T13:34:38Z 2016-07-28T13:34:38Z 2016 Master Thesis Masters MSc (Med) http://hdl.handle.net/11427/21000 eng application/pdf Department of Psychiatry and Mental Health Faculty of Health Sciences University of Cape Town |
| spellingShingle | Neuroscience Burger, Antoinette Investigating the Influence of Methamphetamine on brain metabolism using 1H-MRS |
| thesis_degree_str | Master's |
| title | Investigating the Influence of Methamphetamine on brain metabolism using 1H-MRS |
| title_full | Investigating the Influence of Methamphetamine on brain metabolism using 1H-MRS |
| title_fullStr | Investigating the Influence of Methamphetamine on brain metabolism using 1H-MRS |
| title_full_unstemmed | Investigating the Influence of Methamphetamine on brain metabolism using 1H-MRS |
| title_short | Investigating the Influence of Methamphetamine on brain metabolism using 1H-MRS |
| title_sort | investigating the influence of methamphetamine on brain metabolism using 1h mrs |
| topic | Neuroscience |
| url | http://hdl.handle.net/11427/21000 |
| work_keys_str_mv | AT burgerantoinette investigatingtheinfluenceofmethamphetamineonbrainmetabolismusing1hmrs |