Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Modelling of batch and fed-batch ethanol fermentation
Two series of batch and fed-batch fermentations were carried out using S.cerevisiae in a semi-defined medium containing 200 gl-1 glucose as limiting substrate. Growth rates were calculated and the data used to test the applicability of eight empirical kinetic models. The form proposed by Levenspiel,...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemical Engineering
2016
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613206714777600 |
|---|---|
| access_status_str | Open Access |
| author | Glyn, Julian E H |
| author2 | Hansford, Geoffrey Spearing |
| author_browse | Glyn, Julian E H Hansford, Geoffrey Spearing |
| author_facet | Hansford, Geoffrey Spearing Glyn, Julian E H |
| author_sort | Glyn, Julian E H |
| collection | Thesis |
| description | Two series of batch and fed-batch fermentations were carried out using S.cerevisiae in a semi-defined medium containing 200 gl-1 glucose as limiting substrate. Growth rates were calculated and the data used to test the applicability of eight empirical kinetic models. The form proposed by Levenspiel, combining the concept of a limiting ethanol concentration with a power-law form, gave the best results with these data. Glucose concentration was found to have a far smaller, though not negligible, effect on growth rate under these conditions. It was also observed that in fed-batch fermentations the total substrate uptake rate of the broth became constant soon after commencement of feeding, without cessation of growth. It is suggested that ethanol inhibits the synthesis of a rate-controlling enzyme in the glycolyti·c chain, but no previous work could be found to support or refute this explanation. A quasi-mechanistic model of growth under the condition of constant substrate consumption rate is formulated and discussed. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/21832 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:27.580Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Department of Chemical Engineering |
| publisherStr | Department of Chemical Engineering |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/21832 Modelling of batch and fed-batch ethanol fermentation Glyn, Julian E H Hansford, Geoffrey Spearing Fermentation Alcohol Chemical Engineering Two series of batch and fed-batch fermentations were carried out using S.cerevisiae in a semi-defined medium containing 200 gl-1 glucose as limiting substrate. Growth rates were calculated and the data used to test the applicability of eight empirical kinetic models. The form proposed by Levenspiel, combining the concept of a limiting ethanol concentration with a power-law form, gave the best results with these data. Glucose concentration was found to have a far smaller, though not negligible, effect on growth rate under these conditions. It was also observed that in fed-batch fermentations the total substrate uptake rate of the broth became constant soon after commencement of feeding, without cessation of growth. It is suggested that ethanol inhibits the synthesis of a rate-controlling enzyme in the glycolyti·c chain, but no previous work could be found to support or refute this explanation. A quasi-mechanistic model of growth under the condition of constant substrate consumption rate is formulated and discussed. 2016-09-20T12:31:41Z 2016-09-20T12:31:41Z 1989 Master Thesis Masters MSc (Eng) http://hdl.handle.net/11427/21832 eng application/pdf Department of Chemical Engineering Faculty of Engineering and the Built Environment University of Cape Town |
| spellingShingle | Fermentation Alcohol Chemical Engineering Glyn, Julian E H Modelling of batch and fed-batch ethanol fermentation |
| thesis_degree_str | Master's |
| title | Modelling of batch and fed-batch ethanol fermentation |
| title_full | Modelling of batch and fed-batch ethanol fermentation |
| title_fullStr | Modelling of batch and fed-batch ethanol fermentation |
| title_full_unstemmed | Modelling of batch and fed-batch ethanol fermentation |
| title_short | Modelling of batch and fed-batch ethanol fermentation |
| title_sort | modelling of batch and fed batch ethanol fermentation |
| topic | Fermentation Alcohol Chemical Engineering |
| url | http://hdl.handle.net/11427/21832 |
| work_keys_str_mv | AT glynjulianeh modellingofbatchandfedbatchethanolfermentation |