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Phytochemical studies on traditional medicinal plants with antimalarial activities
The active antimalarial principles of three traditional medicinal plants, Passerina obtusifolia (Thymelaeaceae), Tetradenia riparia (Labiatea) and Xerophyta retinervis (V elloziaceae) were investigated by employing bioassay guided fractionation. Two novel compounds and five known constituents were i...
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| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2016
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| _version_ | 1867613237398208512 |
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| access_status_str | Open Access |
| author | Chen, Dianne Tzu-Hsiu |
| author2 | Gammon, David W |
| author_browse | Chen, Dianne Tzu-Hsiu Gammon, David W |
| author_facet | Gammon, David W Chen, Dianne Tzu-Hsiu |
| author_sort | Chen, Dianne Tzu-Hsiu |
| collection | Thesis |
| description | The active antimalarial principles of three traditional medicinal plants, Passerina obtusifolia (Thymelaeaceae), Tetradenia riparia (Labiatea) and Xerophyta retinervis (V elloziaceae) were investigated by employing bioassay guided fractionation. Two novel compounds and five known constituents were isolated from the active fractions of these three plants. The types of compounds isolated included: three triterpenoids (20(29)-Lupene-3α,28- diol (30), 20(29)-Lupene-3α, 16β,28-triol (32) and 3β-Hydroxy-20(29)-Lupen-28-oic acid (42)); two diterpenoids (8-Abietene-7 β,13 β -diol (45) and cariocal (51)); one flavonoid ( 5-Hydroxy:.4' ,6, 7-trimethoxyflavone ( 44)) and one flavonolignan ( 11-0- acetyl hydnocarpin (62)). In addition, one analogue of 7α-hydroxyroyleanone (41) (which was previously isolated from T riparia and was found to be the active antimalarial principle of the plant) was prepared. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/21853 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:57.328Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/21853 Phytochemical studies on traditional medicinal plants with antimalarial activities Chen, Dianne Tzu-Hsiu Gammon, David W Campbell, William E Chemistry The active antimalarial principles of three traditional medicinal plants, Passerina obtusifolia (Thymelaeaceae), Tetradenia riparia (Labiatea) and Xerophyta retinervis (V elloziaceae) were investigated by employing bioassay guided fractionation. Two novel compounds and five known constituents were isolated from the active fractions of these three plants. The types of compounds isolated included: three triterpenoids (20(29)-Lupene-3α,28- diol (30), 20(29)-Lupene-3α, 16β,28-triol (32) and 3β-Hydroxy-20(29)-Lupen-28-oic acid (42)); two diterpenoids (8-Abietene-7 β,13 β -diol (45) and cariocal (51)); one flavonoid ( 5-Hydroxy:.4' ,6, 7-trimethoxyflavone ( 44)) and one flavonolignan ( 11-0- acetyl hydnocarpin (62)). In addition, one analogue of 7α-hydroxyroyleanone (41) (which was previously isolated from T riparia and was found to be the active antimalarial principle of the plant) was prepared. 2016-09-20T12:35:23Z 2016-09-20T12:35:23Z 1997 Master Thesis Masters MSc http://hdl.handle.net/11427/21853 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Chen, Dianne Tzu-Hsiu Phytochemical studies on traditional medicinal plants with antimalarial activities |
| thesis_degree_str | Master's |
| title | Phytochemical studies on traditional medicinal plants with antimalarial activities |
| title_full | Phytochemical studies on traditional medicinal plants with antimalarial activities |
| title_fullStr | Phytochemical studies on traditional medicinal plants with antimalarial activities |
| title_full_unstemmed | Phytochemical studies on traditional medicinal plants with antimalarial activities |
| title_short | Phytochemical studies on traditional medicinal plants with antimalarial activities |
| title_sort | phytochemical studies on traditional medicinal plants with antimalarial activities |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/21853 |
| work_keys_str_mv | AT chendiannetzuhsiu phytochemicalstudiesontraditionalmedicinalplantswithantimalarialactivities |