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Treatment-resistant ophthalmoplegia in Myasthenia gravis: extraocular muscle pathology, the role of TGFβ1 and the derivation of induced pluripotency towards 'disease-in-a-dish' modeling

Myasthenia gravis (MG) is an autoimmune disease in which pathogenic antibodies target specific neuromuscular junction proteins, most frequently acetylcholine receptors (AChR). Among those without detectable AChR-antibodies, a subgroup of patients has antibodies directed against muscle-specific tyros...

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Bibliographic Details
Main Author: Rautenbach, Robyn Marié
Other Authors: Heckmann, Jeannine M
Format: Thesis
Language:English
Published: Department of Medicine 2017
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