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The use of phenylephrine to obtund oxytocin induced hypotension and tachycardia during elective caesarean section
Background: Oxytocin causes clinically significant hypotension and tachycardia. This study examined whether the prior administration of phenylephrine obtunds these unwanted haemodynamic effects. Methods: Forty pregnant women undergoing elective caesarean section under spinal anaesthesia were randomi...
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| Format: | Thesis |
| Language: | English |
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Department of Anaesthesia
2017
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| _version_ | 1867613197001818112 |
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| access_status_str | Open Access |
| author | Rumboll, Charles Knight |
| author2 | Dyer, Robert A |
| author_browse | Dyer, Robert A Rumboll, Charles Knight |
| author_facet | Dyer, Robert A Rumboll, Charles Knight |
| author_sort | Rumboll, Charles Knight |
| collection | Thesis |
| description | Background: Oxytocin causes clinically significant hypotension and tachycardia. This study examined whether the prior administration of phenylephrine obtunds these unwanted haemodynamic effects. Methods: Forty pregnant women undergoing elective caesarean section under spinal anaesthesia were randomised to receive either a 50 μg bolus of phenylephrine (Group P) or saline (Group S) immediately prior to oxytocin (3 IU over 15 seconds). Systolic blood pressure [SBP], diastolic blood pressure [DBP], mean arterial pressure [MAP] and heart rate [HR]) were recorded using a continuous non-invasive arterial pressure device. Baseline values were averaged for 20 seconds post-delivery. Between-group comparisons were made of the mean peak changes in BP and HR, and the mean percentage changes from baseline, during the 150 seconds after oxytocin administration. Results: The mean peak percentage change (SD) in SBP was -16.9% (2%) in Group P, and -19.0% (1.9%) in Group S and the estimated mean difference was 2.1% (95% CI: -3.5 to 7.8 %) and P =0.44; corresponding changes in HR were 13.5% (2.3%) and 14.0% (1.5%) and the mean estimated difference was 0.5% (95% CI -6.0 to 5%) and P=0.87. The mean percentage change from the baseline measurements during the 150 s period of measurement was greater for Group S than Group P: SBP -5.9% vs -3.4%; P =0.149; DBP -7.2% vs -1.5%, P =0.014; MAP -6.8% vs -1.5%, P =0.007; HR 2.1% vs -2.4%, P =0.033. Conclusion: Intravenous phenylephrine 50 μg immediately before 3 U oxytocin during elective caesarean section does not prevent maternal hypotension and tachycardia. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/22807 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:18.917Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Department of Anaesthesia |
| publisherStr | Department of Anaesthesia |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/22807 The use of phenylephrine to obtund oxytocin induced hypotension and tachycardia during elective caesarean section Rumboll, Charles Knight Dyer, Robert A Anaesthesiology Background: Oxytocin causes clinically significant hypotension and tachycardia. This study examined whether the prior administration of phenylephrine obtunds these unwanted haemodynamic effects. Methods: Forty pregnant women undergoing elective caesarean section under spinal anaesthesia were randomised to receive either a 50 μg bolus of phenylephrine (Group P) or saline (Group S) immediately prior to oxytocin (3 IU over 15 seconds). Systolic blood pressure [SBP], diastolic blood pressure [DBP], mean arterial pressure [MAP] and heart rate [HR]) were recorded using a continuous non-invasive arterial pressure device. Baseline values were averaged for 20 seconds post-delivery. Between-group comparisons were made of the mean peak changes in BP and HR, and the mean percentage changes from baseline, during the 150 seconds after oxytocin administration. Results: The mean peak percentage change (SD) in SBP was -16.9% (2%) in Group P, and -19.0% (1.9%) in Group S and the estimated mean difference was 2.1% (95% CI: -3.5 to 7.8 %) and P =0.44; corresponding changes in HR were 13.5% (2.3%) and 14.0% (1.5%) and the mean estimated difference was 0.5% (95% CI -6.0 to 5%) and P=0.87. The mean percentage change from the baseline measurements during the 150 s period of measurement was greater for Group S than Group P: SBP -5.9% vs -3.4%; P =0.149; DBP -7.2% vs -1.5%, P =0.014; MAP -6.8% vs -1.5%, P =0.007; HR 2.1% vs -2.4%, P =0.033. Conclusion: Intravenous phenylephrine 50 μg immediately before 3 U oxytocin during elective caesarean section does not prevent maternal hypotension and tachycardia. 2017-01-19T12:17:06Z 2017-01-19T12:17:06Z 2016 Master Thesis Masters MMed http://hdl.handle.net/11427/22807 eng application/pdf Department of Anaesthesia Faculty of Health Sciences University of Cape Town |
| spellingShingle | Anaesthesiology Rumboll, Charles Knight The use of phenylephrine to obtund oxytocin induced hypotension and tachycardia during elective caesarean section |
| thesis_degree_str | Master's |
| title | The use of phenylephrine to obtund oxytocin induced hypotension and tachycardia during elective caesarean section |
| title_full | The use of phenylephrine to obtund oxytocin induced hypotension and tachycardia during elective caesarean section |
| title_fullStr | The use of phenylephrine to obtund oxytocin induced hypotension and tachycardia during elective caesarean section |
| title_full_unstemmed | The use of phenylephrine to obtund oxytocin induced hypotension and tachycardia during elective caesarean section |
| title_short | The use of phenylephrine to obtund oxytocin induced hypotension and tachycardia during elective caesarean section |
| title_sort | use of phenylephrine to obtund oxytocin induced hypotension and tachycardia during elective caesarean section |
| topic | Anaesthesiology |
| url | http://hdl.handle.net/11427/22807 |
| work_keys_str_mv | AT rumbollcharlesknight theuseofphenylephrinetoobtundoxytocininducedhypotensionandtachycardiaduringelectivecaesareansection AT rumbollcharlesknight useofphenylephrinetoobtundoxytocininducedhypotensionandtachycardiaduringelectivecaesareansection |