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Fluid-structure interaction modelling of a patient-specific arteriovenous access fistula
This research forms part of an interdisciplinary project that aims to improve the detailed understanding of the haemodynamics and vascular mechanics in arteriovenous shunts that are required for haemodialysis treatments. A combination of new PCMRA imaging and computational modelling of in vivo blood...
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| Format: | Thesis |
| Language: | English |
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Centre for Research in Computational and Applied Mechanics (CERECAM)
2017
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| _version_ | 1867613164279955456 |
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| access_status_str | Open Access |
| author | Guess, Winston |
| author2 | Reddy, B Daya |
| author_browse | Guess, Winston Reddy, B Daya |
| author_facet | Reddy, B Daya Guess, Winston |
| author_sort | Guess, Winston |
| collection | Thesis |
| description | This research forms part of an interdisciplinary project that aims to improve the detailed understanding of the haemodynamics and vascular mechanics in arteriovenous shunts that are required for haemodialysis treatments. A combination of new PCMRA imaging and computational modelling of in vivo blood flow aims to determine the haemodynamic conditions that may lead to the high failure rate of vascular access in these circumstances. This thesis focuses on developing a patient-specific fluid-structure interaction (FSI) model of a PC-MRA imaged arteriovenous fistula. The numerical FSI model is developed and simulated within the commercial multiphysics simulation package ANSYS® Academic Research, Release 16. The blood flow is modelled as a Newtonian fluid with the finite-volume method solver ANSYS® Fluent®. A pulsatile mass-flow boundary condition is applied at the artery inlet and a three-element Windkessel model at the artery and vein outlets. ANSYS® Mechanical™, a finite element method solver, is used to model the nonlinear behaviour of the vessel walls. The artery and vein walls are assumed to follow a third-order Yeoh model, and are differentiated by thickness and by material strength characteristics. The staggered FSI model is configured and executed in ANSYS® Workbench™, forming a semi-implicit coupling of the blood flow and vessel wall models. This work shows the effectiveness of combining a number of stabilisation techniques to simultaneously overcome the added-mass effect and optimise the efficiency of the overall model. The PC-MRA data, fluid model, and FSI model show almost identical flow features in the fistula; this applies in particular to a flow recirculation region in the vein that could potentially lead to fistula failure. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/22840 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:47.142Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Centre for Research in Computational and Applied Mechanics (CERECAM) |
| publisherStr | Centre for Research in Computational and Applied Mechanics (CERECAM) |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/22840 Fluid-structure interaction modelling of a patient-specific arteriovenous access fistula Guess, Winston Reddy, B Daya McBride, Andrew Trevor Mechanical Engineering This research forms part of an interdisciplinary project that aims to improve the detailed understanding of the haemodynamics and vascular mechanics in arteriovenous shunts that are required for haemodialysis treatments. A combination of new PCMRA imaging and computational modelling of in vivo blood flow aims to determine the haemodynamic conditions that may lead to the high failure rate of vascular access in these circumstances. This thesis focuses on developing a patient-specific fluid-structure interaction (FSI) model of a PC-MRA imaged arteriovenous fistula. The numerical FSI model is developed and simulated within the commercial multiphysics simulation package ANSYS® Academic Research, Release 16. The blood flow is modelled as a Newtonian fluid with the finite-volume method solver ANSYS® Fluent®. A pulsatile mass-flow boundary condition is applied at the artery inlet and a three-element Windkessel model at the artery and vein outlets. ANSYS® Mechanical™, a finite element method solver, is used to model the nonlinear behaviour of the vessel walls. The artery and vein walls are assumed to follow a third-order Yeoh model, and are differentiated by thickness and by material strength characteristics. The staggered FSI model is configured and executed in ANSYS® Workbench™, forming a semi-implicit coupling of the blood flow and vessel wall models. This work shows the effectiveness of combining a number of stabilisation techniques to simultaneously overcome the added-mass effect and optimise the efficiency of the overall model. The PC-MRA data, fluid model, and FSI model show almost identical flow features in the fistula; this applies in particular to a flow recirculation region in the vein that could potentially lead to fistula failure. 2017-01-20T07:48:17Z 2017-01-20T07:48:17Z 2016 Master Thesis Masters MSc (Eng) http://hdl.handle.net/11427/22840 eng application/pdf Centre for Research in Computational and Applied Mechanics (CERECAM) Faculty of Engineering and the Built Environment University of Cape Town |
| spellingShingle | Mechanical Engineering Guess, Winston Fluid-structure interaction modelling of a patient-specific arteriovenous access fistula |
| thesis_degree_str | Master's |
| title | Fluid-structure interaction modelling of a patient-specific arteriovenous access fistula |
| title_full | Fluid-structure interaction modelling of a patient-specific arteriovenous access fistula |
| title_fullStr | Fluid-structure interaction modelling of a patient-specific arteriovenous access fistula |
| title_full_unstemmed | Fluid-structure interaction modelling of a patient-specific arteriovenous access fistula |
| title_short | Fluid-structure interaction modelling of a patient-specific arteriovenous access fistula |
| title_sort | fluid structure interaction modelling of a patient specific arteriovenous access fistula |
| topic | Mechanical Engineering |
| url | http://hdl.handle.net/11427/22840 |
| work_keys_str_mv | AT guesswinston fluidstructureinteractionmodellingofapatientspecificarteriovenousaccessfistula |