Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Studies on multiply exposed but persistently HIV-1 seronegative sex workers from KwaZulu/Natal, South Africa
The overall aim of this study was to determine whether host genetic factors are associated with resistance to HIV-1 infection in a group of highly exposed persistently seronegative sex workers from KwaZulu/Natal, South Africa. A cohort of 17 African highly exposed but persistently seronegative (HEPS...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Medical Microbiology
2017
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867614030784364544 |
|---|---|
| access_status_str | Open Access |
| author | Malaza, Abraham Lucky |
| author2 | Williamson, Carolyn |
| author_browse | Malaza, Abraham Lucky Williamson, Carolyn |
| author_facet | Williamson, Carolyn Malaza, Abraham Lucky |
| author_sort | Malaza, Abraham Lucky |
| collection | Thesis |
| description | The overall aim of this study was to determine whether host genetic factors are associated with resistance to HIV-1 infection in a group of highly exposed persistently seronegative sex workers from KwaZulu/Natal, South Africa. A cohort of 17 African highly exposed but persistently seronegative (HEPS) commercial sex workers (CSW) were identified who had been in sex work for more than four years (range between 4-26 years). The women had been followed monthly for at least four years as part of HIV-1 prevention programmes (Ramjee, et al., 1998). The overall aim of this study was to identify the frequency of polymorphisms and mutations in chemokine genes, chemokine receptors and chemokine receptor promoter region which ma y be associated with HIV-1 resistance and prolonged disease progression. Secondly, to determine if the chemokine receptors on CD4 T-cells are sufficiently expressed and functional to enable infection. This information will shed light on correlates of immunity as influenced by these polymorphisms and this knowledge will help in the bigger objective of determining factors influencing disease progression as well as the development of an effective HIV-1 vaccine in South Africa. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/24941 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:45:34.119Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Division of Medical Microbiology |
| publisherStr | Division of Medical Microbiology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/24941 Studies on multiply exposed but persistently HIV-1 seronegative sex workers from KwaZulu/Natal, South Africa Malaza, Abraham Lucky Williamson, Carolyn Morris, Lynn Medical Microbiology The overall aim of this study was to determine whether host genetic factors are associated with resistance to HIV-1 infection in a group of highly exposed persistently seronegative sex workers from KwaZulu/Natal, South Africa. A cohort of 17 African highly exposed but persistently seronegative (HEPS) commercial sex workers (CSW) were identified who had been in sex work for more than four years (range between 4-26 years). The women had been followed monthly for at least four years as part of HIV-1 prevention programmes (Ramjee, et al., 1998). The overall aim of this study was to identify the frequency of polymorphisms and mutations in chemokine genes, chemokine receptors and chemokine receptor promoter region which ma y be associated with HIV-1 resistance and prolonged disease progression. Secondly, to determine if the chemokine receptors on CD4 T-cells are sufficiently expressed and functional to enable infection. This information will shed light on correlates of immunity as influenced by these polymorphisms and this knowledge will help in the bigger objective of determining factors influencing disease progression as well as the development of an effective HIV-1 vaccine in South Africa. 2017-08-23T13:03:58Z 2017-08-23T13:03:58Z 2002 2017-07-11T12:36:05Z Master Thesis Masters MSc (Med) http://hdl.handle.net/11427/24941 eng application/pdf Division of Medical Microbiology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Microbiology Malaza, Abraham Lucky Studies on multiply exposed but persistently HIV-1 seronegative sex workers from KwaZulu/Natal, South Africa |
| thesis_degree_str | Master's |
| title | Studies on multiply exposed but persistently HIV-1 seronegative sex workers from KwaZulu/Natal, South Africa |
| title_full | Studies on multiply exposed but persistently HIV-1 seronegative sex workers from KwaZulu/Natal, South Africa |
| title_fullStr | Studies on multiply exposed but persistently HIV-1 seronegative sex workers from KwaZulu/Natal, South Africa |
| title_full_unstemmed | Studies on multiply exposed but persistently HIV-1 seronegative sex workers from KwaZulu/Natal, South Africa |
| title_short | Studies on multiply exposed but persistently HIV-1 seronegative sex workers from KwaZulu/Natal, South Africa |
| title_sort | studies on multiply exposed but persistently hiv 1 seronegative sex workers from kwazulu natal south africa |
| topic | Medical Microbiology |
| url | http://hdl.handle.net/11427/24941 |
| work_keys_str_mv | AT malazaabrahamlucky studiesonmultiplyexposedbutpersistentlyhiv1seronegativesexworkersfromkwazulunatalsouthafrica |