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Single frequency whole-body impedance studies in children with diarrhoeal disease and development of a variable frequency system
Diarrhoeal disease is a major cause of infant mortality in this and other developing countries. The assessment of the degree of dehydration in these children is often based on subjective findings alone. These have been shown to be inaccurate as an assessment of the degree of dehydration. Whole-body...
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| Format: | Thesis |
| Language: | English English |
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Division of Biomedical Engineering
2017
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| _version_ | 1867613254944030720 |
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| access_status_str | Open Access |
| author | Moshal, David Clive Moshal, David Clive |
| author2 | Bunn, Anthony E |
| author_browse | Bunn, Anthony E Moshal, David Clive |
| author_facet | Bunn, Anthony E Moshal, David Clive Moshal, David Clive |
| author_sort | Moshal, David Clive |
| collection | Thesis |
| description | Diarrhoeal disease is a major cause of infant mortality in this and other developing countries. The assessment of the degree of dehydration in these children is often based on subjective findings alone. These have been shown to be inaccurate as an assessment of the degree of dehydration. Whole-body impedance (WBI) is a method of measuring total body water which is used to assess body composition. This WBI technology, which operates at a single frequency, has been applied to the assessment of dehydration in children with diarrhoeal disease. The normal range of WBI was determined on a group of normally hydrated children and was found to have a mean of 746 Ω, a standard deviation of 85 Ω and 95 % confidence interval for the mean from 720 Ω to 772 Ω. WBI did not depend on age, mass, height or sex. The WBI of a group of children dehydrated from infantile gastroenteritis was measured both before and after rehydration. The dehydrated group had a mean WBI on admission of 1089 Ω and a standard deviation of 149 Ω with a 95 % confidence interval for the mean from 950 Ω to 1109 Ω. This value was significantly greater than that of the normal group. The WBI of the dehydrated group after rehydration was not significantly different from the normal group. In addition a variable frequency bioimpedance analyser was designed and tested. It was found to have an error of less than 1 % over the frequency range 1 to 100 kHz. The device was evaluated on 11 normal and dehydrated children. Four dehydrated children were tested before and after rehydration and this data was compared to a standard electrical model for WBI. It was found that the model could represent the measured data over this frequency range. The extracellular resistive element of the model was mainly responsible for the changes seen during rehydration, suggesting that dehydration in gastroenteritis is mainly due to fluid loss from the ECF compartment. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/24955 |
| institution | University of Cape Town (South Africa) |
| language | eng eng |
| last_indexed | 2026-06-10T12:33:13.838Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Division of Biomedical Engineering |
| publisherStr | Division of Biomedical Engineering |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/24955 Single frequency whole-body impedance studies in children with diarrhoeal disease and development of a variable frequency system Single frequency whole-body impedance studies in children with diarrhoeal disease and development of a variable frequency system Moshal, David Clive Moshal, David Clive Bunn, Anthony E Diarrhea, Infantile Dehydration - In infancy and childhood Electric Impedance Whole-Body Counting - methods Infantile Diarrhea Biomedical Engineering Diarrhoeal disease is a major cause of infant mortality in this and other developing countries. The assessment of the degree of dehydration in these children is often based on subjective findings alone. These have been shown to be inaccurate as an assessment of the degree of dehydration. Whole-body impedance (WBI) is a method of measuring total body water which is used to assess body composition. This WBI technology, which operates at a single frequency, has been applied to the assessment of dehydration in children with diarrhoeal disease. The normal range of WBI was determined on a group of normally hydrated children and was found to have a mean of 746 Ω, a standard deviation of 85 Ω and 95 % confidence interval for the mean from 720 Ω to 772 Ω. WBI did not depend on age, mass, height or sex. The WBI of a group of children dehydrated from infantile gastroenteritis was measured both before and after rehydration. The dehydrated group had a mean WBI on admission of 1089 Ω and a standard deviation of 149 Ω with a 95 % confidence interval for the mean from 950 Ω to 1109 Ω. This value was significantly greater than that of the normal group. The WBI of the dehydrated group after rehydration was not significantly different from the normal group. In addition a variable frequency bioimpedance analyser was designed and tested. It was found to have an error of less than 1 % over the frequency range 1 to 100 kHz. The device was evaluated on 11 normal and dehydrated children. Four dehydrated children were tested before and after rehydration and this data was compared to a standard electrical model for WBI. It was found that the model could represent the measured data over this frequency range. The extracellular resistive element of the model was mainly responsible for the changes seen during rehydration, suggesting that dehydration in gastroenteritis is mainly due to fluid loss from the ECF compartment. 2017-08-23T13:08:42Z 2017-08-23T13:08:42Z 1993 2017-07-12T08:20:42Z Master Thesis Masters MPhil http://hdl.handle.net/11427/24955 eng eng application/pdf Division of Biomedical Engineering Faculty of Health Sciences University of Cape Town University of Cape Town |
| spellingShingle | Diarrhea, Infantile Dehydration - In infancy and childhood Electric Impedance Whole-Body Counting - methods Infantile Diarrhea Biomedical Engineering Moshal, David Clive Moshal, David Clive Single frequency whole-body impedance studies in children with diarrhoeal disease and development of a variable frequency system |
| thesis_degree_str | Master's |
| title | Single frequency whole-body impedance studies in children with diarrhoeal disease and development of a variable frequency system |
| title_full | Single frequency whole-body impedance studies in children with diarrhoeal disease and development of a variable frequency system |
| title_fullStr | Single frequency whole-body impedance studies in children with diarrhoeal disease and development of a variable frequency system |
| title_full_unstemmed | Single frequency whole-body impedance studies in children with diarrhoeal disease and development of a variable frequency system |
| title_short | Single frequency whole-body impedance studies in children with diarrhoeal disease and development of a variable frequency system |
| title_sort | single frequency whole body impedance studies in children with diarrhoeal disease and development of a variable frequency system |
| topic | Diarrhea, Infantile Dehydration - In infancy and childhood Electric Impedance Whole-Body Counting - methods Infantile Diarrhea Biomedical Engineering |
| url | http://hdl.handle.net/11427/24955 |
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