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Studies on aspects of Autonomic Neuropathy in non Insulin dependent Diabetes
Autonomic neuropathy (AN) is a well-recognized complication of diabetes mellitus. It has multiple clinical features and is often associated with debilitation and an increased mortality. However, there appears to be a paucity of knowledge with regard to its effects on hormone release and its biochemi...
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| Format: | Thesis |
| Language: | English English |
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Division of Endocrinology and Diabetology
2017
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| _version_ | 1867613208112529408 |
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| access_status_str | Open Access |
| author | Levitt, Naomi Sharlene Levitt, Naomi Sharlene |
| author2 | Jackson, W P U |
| author_browse | Jackson, W P U Levitt, Naomi Sharlene |
| author_facet | Jackson, W P U Levitt, Naomi Sharlene Levitt, Naomi Sharlene |
| author_sort | Levitt, Naomi Sharlene |
| collection | Thesis |
| description | Autonomic neuropathy (AN) is a well-recognized complication of diabetes mellitus. It has multiple clinical features and is often associated with debilitation and an increased mortality. However, there appears to be a paucity of knowledge with regard to its effects on hormone release and its biochemical sequelae. Recent evidence has accumulated suggesting a role for the autonomic nervous system in regulating release of a number of gastrointestinal hormones. It is therefore possible that autonomic dysfunction may be associated with altered gastrointestinal hormone release and indeed various studies have revealed abnormalities in t he release of these peptides in diabetes mellitus. The prime purpose of this thesis was to provide evidence which might contribute to an understanding of t he interrel a tionship between non insulin dependent diabetes (NIDDM), gastrointestinal hormone release and the autonomic nervous system. Thus studies to evaluate basal and stimulated release of the gastrointestinal hormones gluc a gon (IRG), pancreatic polypeptide (PP), gastrin, gastric inhibitory polypeptide (GIP) and somatostatin (SRIF-LI) have been undertaken in NIDDM. Studies were also carried out to assess whether AN may be implicated in abnormal release of these five gut hormones in diabetes and to determine if one of the hormones, PP, might be used as a marker for AN. Finally the effect of dietary fibre on glucose tolerance was studied to assess whether its effect would be altered in the presence of AN in NIDDM. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/24956 |
| institution | University of Cape Town (South Africa) |
| language | eng eng |
| last_indexed | 2026-06-10T12:32:29.432Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Division of Endocrinology and Diabetology |
| publisherStr | Division of Endocrinology and Diabetology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/24956 Studies on aspects of Autonomic Neuropathy in non Insulin dependent Diabetes Studies on aspects of autonomic neuropathy in non insulin dependent Diabetes Levitt, Naomi Sharlene Levitt, Naomi Sharlene Jackson, W P U Diabetology Autonomic neuropathy (AN) is a well-recognized complication of diabetes mellitus. It has multiple clinical features and is often associated with debilitation and an increased mortality. However, there appears to be a paucity of knowledge with regard to its effects on hormone release and its biochemical sequelae. Recent evidence has accumulated suggesting a role for the autonomic nervous system in regulating release of a number of gastrointestinal hormones. It is therefore possible that autonomic dysfunction may be associated with altered gastrointestinal hormone release and indeed various studies have revealed abnormalities in t he release of these peptides in diabetes mellitus. The prime purpose of this thesis was to provide evidence which might contribute to an understanding of t he interrel a tionship between non insulin dependent diabetes (NIDDM), gastrointestinal hormone release and the autonomic nervous system. Thus studies to evaluate basal and stimulated release of the gastrointestinal hormones gluc a gon (IRG), pancreatic polypeptide (PP), gastrin, gastric inhibitory polypeptide (GIP) and somatostatin (SRIF-LI) have been undertaken in NIDDM. Studies were also carried out to assess whether AN may be implicated in abnormal release of these five gut hormones in diabetes and to determine if one of the hormones, PP, might be used as a marker for AN. Finally the effect of dietary fibre on glucose tolerance was studied to assess whether its effect would be altered in the presence of AN in NIDDM. 2017-08-23T13:09:00Z 2017-08-23T13:09:00Z 1980 2017-05-02T07:15:41Z Doctoral Thesis Doctoral MD http://hdl.handle.net/11427/24956 eng eng application/pdf Division of Endocrinology and Diabetology Faculty of Health Sciences University of Cape Town University of Cape Town |
| spellingShingle | Diabetology Levitt, Naomi Sharlene Levitt, Naomi Sharlene Studies on aspects of Autonomic Neuropathy in non Insulin dependent Diabetes |
| thesis_degree_str | Doctoral |
| title | Studies on aspects of Autonomic Neuropathy in non Insulin dependent Diabetes |
| title_full | Studies on aspects of Autonomic Neuropathy in non Insulin dependent Diabetes |
| title_fullStr | Studies on aspects of Autonomic Neuropathy in non Insulin dependent Diabetes |
| title_full_unstemmed | Studies on aspects of Autonomic Neuropathy in non Insulin dependent Diabetes |
| title_short | Studies on aspects of Autonomic Neuropathy in non Insulin dependent Diabetes |
| title_sort | studies on aspects of autonomic neuropathy in non insulin dependent diabetes |
| topic | Diabetology |
| url | http://hdl.handle.net/11427/24956 |
| work_keys_str_mv | AT levittnaomisharlene studiesonaspectsofautonomicneuropathyinnoninsulindependentdiabetes AT levittnaomisharlene studiesonaspectsofautonomicneuropathyinnoninsulindependentdiabetes |