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The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease
The use of aminoglycosides in the treatment of the febrile neutropaenic patient with haematological disease is difficult and often suboptimal. This study reviews the available literature to establish therapeutic guidelines in this population and then reports the use of a Bayesian statistics based pr...
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| Format: | Thesis |
| Language: | English English |
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Department of Medicine
2017
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| _version_ | 1867613158054559745 |
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| access_status_str | Open Access |
| author | Zent, Clive Steven Zent, Clive Steven |
| author2 | Allin, Rosemary |
| author_browse | Allin, Rosemary Zent, Clive Steven |
| author_facet | Allin, Rosemary Zent, Clive Steven Zent, Clive Steven |
| author_sort | Zent, Clive Steven |
| collection | Thesis |
| description | The use of aminoglycosides in the treatment of the febrile neutropaenic patient with haematological disease is difficult and often suboptimal. This study reviews the available literature to establish therapeutic guidelines in this population and then reports the use of a Bayesian statistics based predictive model to implement and manage therapy in 10 patients. A review of the literature on aminoglycoside Pharmacology and clinical use is essential to determine therapeutic guidelines for this population. Aminoglycosides are amino sugars in glycosidic linkage and are polycations at physiological PH. The antibiotic effect is mediated through inhibition of protein synthesis and disruption of cell membrane integrity. Principal use is in treatment of Gram negative infection although aminoglycosides have activity against some Gram positive organisms including staphylococci. Aminoglycosides are inactive against anaerobes. Acquired resistance is mediated by bacterial enzymatic drug metabolism. Aminoglycosides are nephro- and ototoxic, this is the major constraint in clinical use. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/24969 |
| institution | University of Cape Town (South Africa) |
| language | eng eng |
| last_indexed | 2026-06-10T12:31:41.113Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/24969 The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease Zent, Clive Steven Zent, Clive Steven Allin, Rosemary Folb, Peter I Antibiotics, Aminoglycoside - pharmacology Antibiotics, Aminoglycoside - therapeutic use Hematologic Diseases - drug therapy Neutropenia - drug therapy Antibiotics, Aminoglycoside - pharmacology~Antibiotics, Aminoglycoside - therapeutic use~Hematologic Diseases - drug therapy~Neutropenia - drug therapy The use of aminoglycosides in the treatment of the febrile neutropaenic patient with haematological disease is difficult and often suboptimal. This study reviews the available literature to establish therapeutic guidelines in this population and then reports the use of a Bayesian statistics based predictive model to implement and manage therapy in 10 patients. A review of the literature on aminoglycoside Pharmacology and clinical use is essential to determine therapeutic guidelines for this population. Aminoglycosides are amino sugars in glycosidic linkage and are polycations at physiological PH. The antibiotic effect is mediated through inhibition of protein synthesis and disruption of cell membrane integrity. Principal use is in treatment of Gram negative infection although aminoglycosides have activity against some Gram positive organisms including staphylococci. Aminoglycosides are inactive against anaerobes. Acquired resistance is mediated by bacterial enzymatic drug metabolism. Aminoglycosides are nephro- and ototoxic, this is the major constraint in clinical use. 2017-08-24T07:27:07Z 2017-08-24T07:27:07Z 1991 2017-07-10T12:44:34Z Master Thesis Masters MMed http://hdl.handle.net/11427/24969 eng eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town University of Cape Town |
| spellingShingle | Antibiotics, Aminoglycoside - pharmacology Antibiotics, Aminoglycoside - therapeutic use Hematologic Diseases - drug therapy Neutropenia - drug therapy Antibiotics, Aminoglycoside - pharmacology~Antibiotics, Aminoglycoside - therapeutic use~Hematologic Diseases - drug therapy~Neutropenia - drug therapy Zent, Clive Steven Zent, Clive Steven The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease |
| thesis_degree_str | Master's |
| title | The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease |
| title_full | The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease |
| title_fullStr | The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease |
| title_full_unstemmed | The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease |
| title_short | The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease |
| title_sort | use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease |
| topic | Antibiotics, Aminoglycoside - pharmacology Antibiotics, Aminoglycoside - therapeutic use Hematologic Diseases - drug therapy Neutropenia - drug therapy Antibiotics, Aminoglycoside - pharmacology~Antibiotics, Aminoglycoside - therapeutic use~Hematologic Diseases - drug therapy~Neutropenia - drug therapy |
| url | http://hdl.handle.net/11427/24969 |
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