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Kaposi's sarcoma: Genetic subtypes and clinical correlation in a South African population

Human herpes virus 8 (HHV8) is the aetiological agent of all forms of Kaposi's sarcoma (KS). Seven major subtypes (A, B, C, D, E, F, Z) based on genetic variability of open reading frame (ORF)-K1, have been identified. Numerous studies point to differing tumorigenic and pathogenic properties of the...

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Main Author: Isaacs, Thuraya
Other Authors: Todd, Gail
Format: Thesis
Language:English
Published: Division of Dermatology 2017
Subjects:
Dermatology
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access_status_str Open Access
author Isaacs, Thuraya
author2 Todd, Gail
author_browse Isaacs, Thuraya
Todd, Gail
author_facet Todd, Gail
Isaacs, Thuraya
author_sort Isaacs, Thuraya
collection Thesis
description Human herpes virus 8 (HHV8) is the aetiological agent of all forms of Kaposi's sarcoma (KS). Seven major subtypes (A, B, C, D, E, F, Z) based on genetic variability of open reading frame (ORF)-K1, have been identified. Numerous studies point to differing tumorigenic and pathogenic properties of the HHV8 subtypes. The study objective was to determine the prevalence of the HHV8 subtypes in a cohort of clinical and histologically confirmed KS in Cape Town, South Africa, and analyse associations between the different subtypes, clinico- epidemiological forms and clinical presentation of KS. The clinical data was prospectively collected and recorded on a body diagram and with photographs. Demographic data was retrospectively collected from clinical records. Tissue biopsies were taken for ORF-K1 subtyping. Out of a cohort of 103, eighty six patients were subtyped; 81 AIDS (aquired immune deficiency syndrome)-KS and 5 African endemic. Subtype A5 (42/86) and B2 (16/86) predominated. B1, B3, A1 and A4 subtypes were identified in 10/86, 9/86, 4/86 and 1/86 patients respectively. A5, B1, B2 and B3 were found in African blacks and individuals of mixed ancestry, while subtypes A1 and A4 are found only in whites and individuals of mixed ancestry. Subtype A5 was associated with >10 KS lesions at presentation in the AIDS-cohort (32/38, p=0,050), but not in the African endemic patients (2/4, p=0,600). Subtypes A1 and A4 were less likely to be associated with poor risk tumour extension (p=0,031) and A1 was associated with lower likelihood of lower limb involvement (p=0,004).
format Thesis
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institution University of Cape Town (South Africa)
language eng
last_indexed 2026-06-10T12:33:05.164Z
license_str Not specified — see source repository
provenance_str_mv Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository
publishDate 2017
publishDateRange 2017
publishDateSort 2017
publisher Division of Dermatology
publisherStr Division of Dermatology
record_format dspace
source_str UCTD — University of Cape Town Open Access Repository
spelling oai:open.uct.ac.za:11427/25281 Kaposi's sarcoma: Genetic subtypes and clinical correlation in a South African population Isaacs, Thuraya Todd, Gail Katz, Arieh A Dermatology Human herpes virus 8 (HHV8) is the aetiological agent of all forms of Kaposi's sarcoma (KS). Seven major subtypes (A, B, C, D, E, F, Z) based on genetic variability of open reading frame (ORF)-K1, have been identified. Numerous studies point to differing tumorigenic and pathogenic properties of the HHV8 subtypes. The study objective was to determine the prevalence of the HHV8 subtypes in a cohort of clinical and histologically confirmed KS in Cape Town, South Africa, and analyse associations between the different subtypes, clinico- epidemiological forms and clinical presentation of KS. The clinical data was prospectively collected and recorded on a body diagram and with photographs. Demographic data was retrospectively collected from clinical records. Tissue biopsies were taken for ORF-K1 subtyping. Out of a cohort of 103, eighty six patients were subtyped; 81 AIDS (aquired immune deficiency syndrome)-KS and 5 African endemic. Subtype A5 (42/86) and B2 (16/86) predominated. B1, B3, A1 and A4 subtypes were identified in 10/86, 9/86, 4/86 and 1/86 patients respectively. A5, B1, B2 and B3 were found in African blacks and individuals of mixed ancestry, while subtypes A1 and A4 are found only in whites and individuals of mixed ancestry. Subtype A5 was associated with >10 KS lesions at presentation in the AIDS-cohort (32/38, p=0,050), but not in the African endemic patients (2/4, p=0,600). Subtypes A1 and A4 were less likely to be associated with poor risk tumour extension (p=0,031) and A1 was associated with lower likelihood of lower limb involvement (p=0,004). 2017-09-22T11:58:13Z 2017-09-22T11:58:13Z 2017 Master Thesis Masters MMed http://hdl.handle.net/11427/25281 eng application/pdf Division of Dermatology Faculty of Health Sciences University of Cape Town
spellingShingle Dermatology
Isaacs, Thuraya
Kaposi's sarcoma: Genetic subtypes and clinical correlation in a South African population
thesis_degree_str Master's
title Kaposi's sarcoma: Genetic subtypes and clinical correlation in a South African population
title_full Kaposi's sarcoma: Genetic subtypes and clinical correlation in a South African population
title_fullStr Kaposi's sarcoma: Genetic subtypes and clinical correlation in a South African population
title_full_unstemmed Kaposi's sarcoma: Genetic subtypes and clinical correlation in a South African population
title_short Kaposi's sarcoma: Genetic subtypes and clinical correlation in a South African population
title_sort kaposi s sarcoma genetic subtypes and clinical correlation in a south african population
topic Dermatology
url http://hdl.handle.net/11427/25281
work_keys_str_mv AT isaacsthuraya kaposissarcomageneticsubtypesandclinicalcorrelationinasouthafricanpopulation

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