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Electrophysiological mechanism of ventricular automaticity : a model foe ventricular arrythmias
Ventricular arrhythmias are difficult to study in man. The current experimental models are arrhythmias induced by electrical stimulation, coronary artery ligation or by subsequent reperfusion. An electrophysiological model will be useful for exploring the cellular mechanism of arrhythmias and for st...
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| Other Authors: | |
| Format: | Thesis |
| Language: | English English |
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MRC/UCT Cape Heart Centre
2017
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| _version_ | 1867613264909697024 |
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| access_status_str | Open Access |
| author | Saman, Selva Saman, Selva |
| author2 | Opie, Lionel H |
| author_browse | Opie, Lionel H Saman, Selva |
| author_facet | Opie, Lionel H Saman, Selva Saman, Selva |
| author_sort | Saman, Selva |
| collection | Thesis |
| description | Ventricular arrhythmias are difficult to study in man. The current experimental models are arrhythmias induced by electrical stimulation, coronary artery ligation or by subsequent reperfusion. An electrophysiological model will be useful for exploring the cellular mechanism of arrhythmias and for studying the mechanism of action of new anti-arrhythmic drugs. This project seeks to establish automaticity as a model for studying ventricular arrhythmias. Objectives 1. To review the literature on the mechanism of ventricular arrhythmias. 2. To explore ventricular automaticity induced by "reperfusion" after O₂ and substrate deprivation. 3 . To explore beta-adrenoceptor mediated ventricular automaticity. 4 . To evaluate possible new anti-arrhythmic drugs, carminomycin and ketanserin. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/25564 |
| institution | University of Cape Town (South Africa) |
| language | eng eng |
| last_indexed | 2026-06-10T12:33:23.204Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | MRC/UCT Cape Heart Centre |
| publisherStr | MRC/UCT Cape Heart Centre |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/25564 Electrophysiological mechanism of ventricular automaticity : a model foe ventricular arrythmias Electrophysiological mechanism of ventricular automaticity : a model for ventricular arrythmias Saman, Selva Saman, Selva Opie, Lionel H Electrophysiology Ventricular fibrillation - Aetiology Electrophysiology~Ventricular fibrillation - Aetiology Arrhythmia Ventricular arrhythmias are difficult to study in man. The current experimental models are arrhythmias induced by electrical stimulation, coronary artery ligation or by subsequent reperfusion. An electrophysiological model will be useful for exploring the cellular mechanism of arrhythmias and for studying the mechanism of action of new anti-arrhythmic drugs. This project seeks to establish automaticity as a model for studying ventricular arrhythmias. Objectives 1. To review the literature on the mechanism of ventricular arrhythmias. 2. To explore ventricular automaticity induced by "reperfusion" after O₂ and substrate deprivation. 3 . To explore beta-adrenoceptor mediated ventricular automaticity. 4 . To evaluate possible new anti-arrhythmic drugs, carminomycin and ketanserin. 2017-10-11T10:48:05Z 2017-10-11T10:48:05Z 1984 2017-07-11T12:39:30Z Master Thesis Masters MD http://hdl.handle.net/11427/25564 eng eng application/pdf MRC/UCT Cape Heart Centre Faculty of Health Sciences University of Cape Town University of Cape Town |
| spellingShingle | Electrophysiology Ventricular fibrillation - Aetiology Electrophysiology~Ventricular fibrillation - Aetiology Arrhythmia Saman, Selva Saman, Selva Electrophysiological mechanism of ventricular automaticity : a model foe ventricular arrythmias |
| thesis_degree_str | Master's |
| title | Electrophysiological mechanism of ventricular automaticity : a model foe ventricular arrythmias |
| title_full | Electrophysiological mechanism of ventricular automaticity : a model foe ventricular arrythmias |
| title_fullStr | Electrophysiological mechanism of ventricular automaticity : a model foe ventricular arrythmias |
| title_full_unstemmed | Electrophysiological mechanism of ventricular automaticity : a model foe ventricular arrythmias |
| title_short | Electrophysiological mechanism of ventricular automaticity : a model foe ventricular arrythmias |
| title_sort | electrophysiological mechanism of ventricular automaticity a model foe ventricular arrythmias |
| topic | Electrophysiology Ventricular fibrillation - Aetiology Electrophysiology~Ventricular fibrillation - Aetiology Arrhythmia |
| url | http://hdl.handle.net/11427/25564 |
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