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Intestinal permeability to polyethylene glycol 400 in patients with Crohn's disease
An altered small intestinal permeability has been proposed as an important aetiological factor in the pathogenesis of inflammatory bowel disease. The relevant literature was reviewed. Intestinal permeability to Polyethylene glycol 400 in patients with Crohn' s disease, their relatives and healthy co...
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| Format: | Thesis |
| Language: | English |
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Department of Medicine
2017
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| _version_ | 1867613866331996160 |
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| access_status_str | Open Access |
| author | Ruttenberg, David |
| author_browse | Ruttenberg, David |
| author_facet | Ruttenberg, David |
| author_sort | Ruttenberg, David |
| collection | Thesis |
| description | An altered small intestinal permeability has been proposed as an important aetiological factor in the pathogenesis of inflammatory bowel disease. The relevant literature was reviewed. Intestinal permeability to Polyethylene glycol 400 in patients with Crohn' s disease, their relatives and healthy controls was examined and the data compared with studies of small bowel permeability to other similar sized probes. A new technique of analysis of urinary Polythylene Glycol 400 by High Performance Liquid Chromatography was described and compared with a previously established HPLC method. No evidence of an altered bowel permeability could be found using Polyethylene glycol 400, but the possibility that this may have been related to probe size and characteristics can not be excluded . |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/25587 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:42:57.285Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/25587 Intestinal permeability to polyethylene glycol 400 in patients with Crohn's disease Ruttenberg, David Crohn Disease - etiology Polyethylene Glycols - analysis An altered small intestinal permeability has been proposed as an important aetiological factor in the pathogenesis of inflammatory bowel disease. The relevant literature was reviewed. Intestinal permeability to Polyethylene glycol 400 in patients with Crohn' s disease, their relatives and healthy controls was examined and the data compared with studies of small bowel permeability to other similar sized probes. A new technique of analysis of urinary Polythylene Glycol 400 by High Performance Liquid Chromatography was described and compared with a previously established HPLC method. No evidence of an altered bowel permeability could be found using Polyethylene glycol 400, but the possibility that this may have been related to probe size and characteristics can not be excluded . 2017-10-11T12:05:13Z 2017-10-11T12:05:13Z 1993 2017-07-12T11:34:41Z Master Thesis Masters MSc http://hdl.handle.net/11427/25587 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Crohn Disease - etiology Polyethylene Glycols - analysis Ruttenberg, David Intestinal permeability to polyethylene glycol 400 in patients with Crohn's disease |
| thesis_degree_str | Master's |
| title | Intestinal permeability to polyethylene glycol 400 in patients with Crohn's disease |
| title_full | Intestinal permeability to polyethylene glycol 400 in patients with Crohn's disease |
| title_fullStr | Intestinal permeability to polyethylene glycol 400 in patients with Crohn's disease |
| title_full_unstemmed | Intestinal permeability to polyethylene glycol 400 in patients with Crohn's disease |
| title_short | Intestinal permeability to polyethylene glycol 400 in patients with Crohn's disease |
| title_sort | intestinal permeability to polyethylene glycol 400 in patients with crohn s disease |
| topic | Crohn Disease - etiology Polyethylene Glycols - analysis |
| url | http://hdl.handle.net/11427/25587 |
| work_keys_str_mv | AT ruttenbergdavid intestinalpermeabilitytopolyethyleneglycol400inpatientswithcrohnsdisease |