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Characterization of a polypeptide factor that inhibits the growth of a human breast cancer line in vitro
This thesis concerns a melanoma-derived growth regulatory factor that inhibited proliferation of several malignant human cell lines, and, in particular, a line designated UCT-BR-1, which was derived from a human breast cancer metastasis. The work is presented in four chapters. Chapter 1 provides a r...
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| Format: | Thesis |
| Language: | English |
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Division of Clinical Immunology
2017
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| _version_ | 1867613231915204608 |
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| access_status_str | Open Access |
| author | Harris, Neil S |
| author2 | Dowdle, Eugene B |
| author_browse | Dowdle, Eugene B Harris, Neil S |
| author_facet | Dowdle, Eugene B Harris, Neil S |
| author_sort | Harris, Neil S |
| collection | Thesis |
| description | This thesis concerns a melanoma-derived growth regulatory factor that inhibited proliferation of several malignant human cell lines, and, in particular, a line designated UCT-BR-1, which was derived from a human breast cancer metastasis. The work is presented in four chapters. Chapter 1 provides a review of the relevant literature at the time of writing; Chapters 2 and 3 describe the experimental work that was done; and in Chapter 4 I discuss the implications of my results for current and future work in growth factors. Experimental results are presented as Charts (which may be Figures or Tables) and the methods and experimental protocols that I used are described in the Chart legends and not in the main text of the thesis. The Appendix contains details of the tissue culture techniques and descriptions of the cell lines that were used. Sources of the various laboratory materials as well as the methods that were employed for the more routine procedures are also described in the appendix. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/25852 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:51.499Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Division of Clinical Immunology |
| publisherStr | Division of Clinical Immunology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/25852 Characterization of a polypeptide factor that inhibits the growth of a human breast cancer line in vitro Harris, Neil S Dowdle, Eugene B Breast - Cancer - Prevention Growth inhibiting substances Peptides Breast Neoplasms - prevention & control Growth Inhibitors Peptides - antagonists and inhibitors This thesis concerns a melanoma-derived growth regulatory factor that inhibited proliferation of several malignant human cell lines, and, in particular, a line designated UCT-BR-1, which was derived from a human breast cancer metastasis. The work is presented in four chapters. Chapter 1 provides a review of the relevant literature at the time of writing; Chapters 2 and 3 describe the experimental work that was done; and in Chapter 4 I discuss the implications of my results for current and future work in growth factors. Experimental results are presented as Charts (which may be Figures or Tables) and the methods and experimental protocols that I used are described in the Chart legends and not in the main text of the thesis. The Appendix contains details of the tissue culture techniques and descriptions of the cell lines that were used. Sources of the various laboratory materials as well as the methods that were employed for the more routine procedures are also described in the appendix. 2017-10-27T06:51:24Z 2017-10-27T06:51:24Z 1988 2017-04-24T14:10:04Z Master Thesis Masters MD http://hdl.handle.net/11427/25852 eng application/pdf Division of Clinical Immunology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Breast - Cancer - Prevention Growth inhibiting substances Peptides Breast Neoplasms - prevention & control Growth Inhibitors Peptides - antagonists and inhibitors Harris, Neil S Characterization of a polypeptide factor that inhibits the growth of a human breast cancer line in vitro |
| thesis_degree_str | Master's |
| title | Characterization of a polypeptide factor that inhibits the growth of a human breast cancer line in vitro |
| title_full | Characterization of a polypeptide factor that inhibits the growth of a human breast cancer line in vitro |
| title_fullStr | Characterization of a polypeptide factor that inhibits the growth of a human breast cancer line in vitro |
| title_full_unstemmed | Characterization of a polypeptide factor that inhibits the growth of a human breast cancer line in vitro |
| title_short | Characterization of a polypeptide factor that inhibits the growth of a human breast cancer line in vitro |
| title_sort | characterization of a polypeptide factor that inhibits the growth of a human breast cancer line in vitro |
| topic | Breast - Cancer - Prevention Growth inhibiting substances Peptides Breast Neoplasms - prevention & control Growth Inhibitors Peptides - antagonists and inhibitors |
| url | http://hdl.handle.net/11427/25852 |
| work_keys_str_mv | AT harrisneils characterizationofapolypeptidefactorthatinhibitsthegrowthofahumanbreastcancerlineinvitro |