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Adenosine and its role in cardioplegia : experimental evaluation in the isolated rat heart and in an-vivo primate model
This study was designed to investigate the role of adenosine, an endogenous cardioprotectant agent, without high potassium and as cardioplegic additive to high potassium solutions. Adenosine cardioplegia and potassium cardioplegia supplemented by adenosine (K + ADO) were investigated in terms of hem...
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| Format: | Thesis |
| Language: | English |
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Division of Cardiology
2017
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| _version_ | 1867613274684522497 |
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| access_status_str | Open Access |
| author | Boehm, Dieter Hermann |
| author2 | Opie, Lionel H |
| author_browse | Boehm, Dieter Hermann Opie, Lionel H |
| author_facet | Opie, Lionel H Boehm, Dieter Hermann |
| author_sort | Boehm, Dieter Hermann |
| collection | Thesis |
| description | This study was designed to investigate the role of adenosine, an endogenous cardioprotectant agent, without high potassium and as cardioplegic additive to high potassium solutions. Adenosine cardioplegia and potassium cardioplegia supplemented by adenosine (K + ADO) were investigated in terms of hemodynamic, metabolic and ultrastructural recovery in the isolated rat heart and in the in-vivo baboon model during periods of global myocardial ischemia, simulating the clinical situation during open heart surgery. The results obtained in both models show that adenosine improved postischemic hemodynamic function when used without high potassium cardioplegia. The combination of adenosine and high potassium was less effective in both models in terms of hemodynamic recovery; however, improved rhythm stability and coronary vasodilatation were still present. In addition adenosine alone was able to induce fast electromechanical arrest in the isolated rat heart. However, failure of even high concentrations of adenosine to limit ventricular fibrillation in the baboon exclude its use as cardioplegic agent on its own without additional interventions. It appears likely that adenosine without high potassium is cardioprotective via activation of A₁ receptors and opening of ATP-sensitive potassium channels, a mechanism which is probably non-functional in a high potassium environment. In view of the limited cardioprotection achieved with the combination of adenosine and high potassium further studies should aim for additional interventions to induce cardioplegia with adenosine and normokalemic solutions. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/26180 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:31.121Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Division of Cardiology |
| publisherStr | Division of Cardiology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/26180 Adenosine and its role in cardioplegia : experimental evaluation in the isolated rat heart and in an-vivo primate model Boehm, Dieter Hermann Opie, Lionel H Reichart, B Cardiothoracic Surgery This study was designed to investigate the role of adenosine, an endogenous cardioprotectant agent, without high potassium and as cardioplegic additive to high potassium solutions. Adenosine cardioplegia and potassium cardioplegia supplemented by adenosine (K + ADO) were investigated in terms of hemodynamic, metabolic and ultrastructural recovery in the isolated rat heart and in the in-vivo baboon model during periods of global myocardial ischemia, simulating the clinical situation during open heart surgery. The results obtained in both models show that adenosine improved postischemic hemodynamic function when used without high potassium cardioplegia. The combination of adenosine and high potassium was less effective in both models in terms of hemodynamic recovery; however, improved rhythm stability and coronary vasodilatation were still present. In addition adenosine alone was able to induce fast electromechanical arrest in the isolated rat heart. However, failure of even high concentrations of adenosine to limit ventricular fibrillation in the baboon exclude its use as cardioplegic agent on its own without additional interventions. It appears likely that adenosine without high potassium is cardioprotective via activation of A₁ receptors and opening of ATP-sensitive potassium channels, a mechanism which is probably non-functional in a high potassium environment. In view of the limited cardioprotection achieved with the combination of adenosine and high potassium further studies should aim for additional interventions to induce cardioplegia with adenosine and normokalemic solutions. 2017-11-13T08:15:04Z 2017-11-13T08:15:04Z 1997 2017-05-17T11:45:53Z Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/26180 eng application/pdf Division of Cardiology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Cardiothoracic Surgery Boehm, Dieter Hermann Adenosine and its role in cardioplegia : experimental evaluation in the isolated rat heart and in an-vivo primate model |
| thesis_degree_str | Doctoral |
| title | Adenosine and its role in cardioplegia : experimental evaluation in the isolated rat heart and in an-vivo primate model |
| title_full | Adenosine and its role in cardioplegia : experimental evaluation in the isolated rat heart and in an-vivo primate model |
| title_fullStr | Adenosine and its role in cardioplegia : experimental evaluation in the isolated rat heart and in an-vivo primate model |
| title_full_unstemmed | Adenosine and its role in cardioplegia : experimental evaluation in the isolated rat heart and in an-vivo primate model |
| title_short | Adenosine and its role in cardioplegia : experimental evaluation in the isolated rat heart and in an-vivo primate model |
| title_sort | adenosine and its role in cardioplegia experimental evaluation in the isolated rat heart and in an vivo primate model |
| topic | Cardiothoracic Surgery |
| url | http://hdl.handle.net/11427/26180 |
| work_keys_str_mv | AT boehmdieterhermann adenosineanditsroleincardioplegiaexperimentalevaluationintheisolatedratheartandinanvivoprimatemodel |