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Preliminary investigation of a possible dose rate effect on survival of cells irradiated with low energy protons
Apparatus has been developed for the irradiation of V79-379A Chinese hamster lung fibroblast cells with 3.6 MeV protons from the Van de Graaff accelerator at the National Accelerator Centre in Faure. The original intention of this work was to investigate and measure a possible dose rate effect on th...
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| Format: | Thesis |
| Language: | English |
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Department of Physics
2017
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| _version_ | 1867613170913247232 |
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| access_status_str | Open Access |
| author | Robinson, L P G |
| author2 | Cherry, R D |
| author_browse | Cherry, R D Robinson, L P G |
| author_facet | Cherry, R D Robinson, L P G |
| author_sort | Robinson, L P G |
| collection | Thesis |
| description | Apparatus has been developed for the irradiation of V79-379A Chinese hamster lung fibroblast cells with 3.6 MeV protons from the Van de Graaff accelerator at the National Accelerator Centre in Faure. The original intention of this work was to investigate and measure a possible dose rate effect on the survival of V79 cells, in the dose range from zero to 25 Gy, at dose rates of about 3 Gy/s and 300 Gy/s. The survival curves initially obtained were anomalous in that they showed abnormally high levels of survival and a tendency to remain at a constant survival level for doses above 10 Gy. Systematic attempts to correct this observed anomaly, involved the following; apparatus improvements were made, a means of measuring the beam profile was devised, the current measuring device and the dosimetry were improved and a possible dose rate effect on intracellular oxygen was investigated. After these improvements, the anomalous effect was much reduced, but not entirely eliminated. The final results showed no significant difference between the survival of cells irradiated at dose rates of about 3 Gy/s and 300 Gy/s; qualitative differences were however noticeable. After correction for the effect of a non-uniform beam profile, the survival curves were significantly different to published work. This difference suggested a possible dose rate effect between dose rates of about 0.1 Gy/s and dose rates above 3 Gy/s. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/26226 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:53.390Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Department of Physics |
| publisherStr | Department of Physics |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/26226 Preliminary investigation of a possible dose rate effect on survival of cells irradiated with low energy protons Robinson, L P G Cherry, R D Jones, Dan T L Bohm, L Pathology, Cellular Hamsters - Cytology Apparatus has been developed for the irradiation of V79-379A Chinese hamster lung fibroblast cells with 3.6 MeV protons from the Van de Graaff accelerator at the National Accelerator Centre in Faure. The original intention of this work was to investigate and measure a possible dose rate effect on the survival of V79 cells, in the dose range from zero to 25 Gy, at dose rates of about 3 Gy/s and 300 Gy/s. The survival curves initially obtained were anomalous in that they showed abnormally high levels of survival and a tendency to remain at a constant survival level for doses above 10 Gy. Systematic attempts to correct this observed anomaly, involved the following; apparatus improvements were made, a means of measuring the beam profile was devised, the current measuring device and the dosimetry were improved and a possible dose rate effect on intracellular oxygen was investigated. After these improvements, the anomalous effect was much reduced, but not entirely eliminated. The final results showed no significant difference between the survival of cells irradiated at dose rates of about 3 Gy/s and 300 Gy/s; qualitative differences were however noticeable. After correction for the effect of a non-uniform beam profile, the survival curves were significantly different to published work. This difference suggested a possible dose rate effect between dose rates of about 0.1 Gy/s and dose rates above 3 Gy/s. 2017-11-14T13:43:38Z 2017-11-14T13:43:38Z 1989 2017-03-24T13:17:07Z Master Thesis Masters MSc http://hdl.handle.net/11427/26226 eng application/pdf Department of Physics Faculty of Science University of Cape Town |
| spellingShingle | Pathology, Cellular Hamsters - Cytology Robinson, L P G Preliminary investigation of a possible dose rate effect on survival of cells irradiated with low energy protons |
| thesis_degree_str | Master's |
| title | Preliminary investigation of a possible dose rate effect on survival of cells irradiated with low energy protons |
| title_full | Preliminary investigation of a possible dose rate effect on survival of cells irradiated with low energy protons |
| title_fullStr | Preliminary investigation of a possible dose rate effect on survival of cells irradiated with low energy protons |
| title_full_unstemmed | Preliminary investigation of a possible dose rate effect on survival of cells irradiated with low energy protons |
| title_short | Preliminary investigation of a possible dose rate effect on survival of cells irradiated with low energy protons |
| title_sort | preliminary investigation of a possible dose rate effect on survival of cells irradiated with low energy protons |
| topic | Pathology, Cellular Hamsters - Cytology |
| url | http://hdl.handle.net/11427/26226 |
| work_keys_str_mv | AT robinsonlpg preliminaryinvestigationofapossibledoserateeffectonsurvivalofcellsirradiatedwithlowenergyprotons |