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Strategies to improve artificial insemination by donor
Artificial insemination with donor sperm is a widely accepted form of treatment for severe male factor infertility. The introduction of quarantined, cryopreserved semen and the associated reduction in cycle fecundity when compared to fresh semen necessitated the development of strategies to improve...
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| Format: | Thesis |
| Language: | English |
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Department of Obstetrics and Gynaecology
2017
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| _version_ | 1867613792519585792 |
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| access_status_str | Open Access |
| author | Dyer, Silke Juliane |
| author2 | van der Spuy, Zephne Margaret |
| author_browse | Dyer, Silke Juliane van der Spuy, Zephne Margaret |
| author_facet | van der Spuy, Zephne Margaret Dyer, Silke Juliane |
| author_sort | Dyer, Silke Juliane |
| collection | Thesis |
| description | Artificial insemination with donor sperm is a widely accepted form of treatment for severe male factor infertility. The introduction of quarantined, cryopreserved semen and the associated reduction in cycle fecundity when compared to fresh semen necessitated the development of strategies to improve the performance of frozen sperm. A prospective randomised clinical trail was undertaken in the Reproductive Medicine Unit at Groote Schuur Hospital to compare intrauterine insemination with intracervical insemination in a therapeutic donor insemination program with cryopreserved semen. The method of insemination was alternated in successive cycles in each patient after intitial randomised selection. Forty three patients underwent 61 intracervical insemination cycles and 48 intrauterine insemination cycles. Strict cycle control was exercised and the timing and frequency of insemination followed a specific protocol. Eighteen clinical pregnancies occurred following eleven intrauterine insemination cycles (22.9% per cycle) and seven intracervical insemination cycles (11.5% per cycle). Treatment outcome was influenced by patient age, the severity of the male factor and endometriosis. Most pregnancies followed insemination with 15 to 25 million motile sperm. Sperm fecundity differed amongst donors. The findings of our study and the current literature suggest that intrauterine insemination improves cycle fecundity in therapeutic donor insemination cycles with frozen donor sperm. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/26264 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:41:46.892Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Department of Obstetrics and Gynaecology |
| publisherStr | Department of Obstetrics and Gynaecology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/26264 Strategies to improve artificial insemination by donor Dyer, Silke Juliane van der Spuy, Zephne Margaret Obstetrics and Gynaecology Artificial insemination with donor sperm is a widely accepted form of treatment for severe male factor infertility. The introduction of quarantined, cryopreserved semen and the associated reduction in cycle fecundity when compared to fresh semen necessitated the development of strategies to improve the performance of frozen sperm. A prospective randomised clinical trail was undertaken in the Reproductive Medicine Unit at Groote Schuur Hospital to compare intrauterine insemination with intracervical insemination in a therapeutic donor insemination program with cryopreserved semen. The method of insemination was alternated in successive cycles in each patient after intitial randomised selection. Forty three patients underwent 61 intracervical insemination cycles and 48 intrauterine insemination cycles. Strict cycle control was exercised and the timing and frequency of insemination followed a specific protocol. Eighteen clinical pregnancies occurred following eleven intrauterine insemination cycles (22.9% per cycle) and seven intracervical insemination cycles (11.5% per cycle). Treatment outcome was influenced by patient age, the severity of the male factor and endometriosis. Most pregnancies followed insemination with 15 to 25 million motile sperm. Sperm fecundity differed amongst donors. The findings of our study and the current literature suggest that intrauterine insemination improves cycle fecundity in therapeutic donor insemination cycles with frozen donor sperm. 2017-11-15T07:37:02Z 2017-11-15T07:37:02Z 1997 2017-03-31T14:07:11Z Master Thesis Masters MMed http://hdl.handle.net/11427/26264 eng application/pdf Department of Obstetrics and Gynaecology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Obstetrics and Gynaecology Dyer, Silke Juliane Strategies to improve artificial insemination by donor |
| thesis_degree_str | Master's |
| title | Strategies to improve artificial insemination by donor |
| title_full | Strategies to improve artificial insemination by donor |
| title_fullStr | Strategies to improve artificial insemination by donor |
| title_full_unstemmed | Strategies to improve artificial insemination by donor |
| title_short | Strategies to improve artificial insemination by donor |
| title_sort | strategies to improve artificial insemination by donor |
| topic | Obstetrics and Gynaecology |
| url | http://hdl.handle.net/11427/26264 |
| work_keys_str_mv | AT dyersilkejuliane strategiestoimproveartificialinseminationbydonor |