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The elderly, arginine vasopressin & selective serotonin reuptake inhibitors
The association between selective serotonin reuptake inhibitors (SSRis) and hyponatraemia has been well documented, the elderly appearing to be at greatest risk. An analysis of data of hyponatraemia in the elderly using SSRis from all published cases and from the Committee on Safety of Medicines fou...
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| Format: | Thesis |
| Language: | English |
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Department of Psychiatry and Mental Health
2017
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| _version_ | 1867613230278377472 |
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| access_status_str | Open Access |
| author | Kirchner, Vincent |
| author2 | Kaliski, Sean |
| author_browse | Kaliski, Sean Kirchner, Vincent |
| author_facet | Kaliski, Sean Kirchner, Vincent |
| author_sort | Kirchner, Vincent |
| collection | Thesis |
| description | The association between selective serotonin reuptake inhibitors (SSRis) and hyponatraemia has been well documented, the elderly appearing to be at greatest risk. An analysis of data of hyponatraemia in the elderly using SSRis from all published cases and from the Committee on Safety of Medicines found that the mean time to detection was about 3 weeks after commencing SSRis. A wide range of time to detection (1-253 days) and non-specific symptoms suggest hyponatraemia is detected by chance rather than being specifically looked for. This is probably a sporadic, idiosyncratic phenomenon that is not dose related as A VP function determined by serum and urine concentrations was found to be normal in six elderly patients using sertraline. In the elderly there are physiological changes, a high prevalence of medical illnesses and concomitant drug use which may precipitate hyponatraemia. Together with a risk of altered water regulation in psychiatric illness this may account for the particular susceptibility of this group to hyponatraemia whilst using SSRis. AIMS & HYPOTHESIS: This dissertation will explore the physiology of Arginine V asopressin and how changes in this system along with other physiological changes in the elderly make the elderly susceptible to hyponatraemia. This problem will then be explored in the context of elderly people with depression using SSRis which are known to cause hyponatraemia. In the first part of the research section the aims are to report the published cases of hyponatraemia occurring whilst using SSRis from the United Kingdom and specifically focus on cases in people 60 years and older. Secondly to re-analyse all case reports in the literature looking only at this population. The third aim was to investigate whether dysregulation of vasopressin function in the elderly using SSRis is a sporadic or usual phenomenon. The null hypothesis is that A VP function is not disturbed by SSRis. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/26271 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:50.328Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Department of Psychiatry and Mental Health |
| publisherStr | Department of Psychiatry and Mental Health |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/26271 The elderly, arginine vasopressin & selective serotonin reuptake inhibitors Kirchner, Vincent Kaliski, Sean Hyponatraemia Psychiatry The association between selective serotonin reuptake inhibitors (SSRis) and hyponatraemia has been well documented, the elderly appearing to be at greatest risk. An analysis of data of hyponatraemia in the elderly using SSRis from all published cases and from the Committee on Safety of Medicines found that the mean time to detection was about 3 weeks after commencing SSRis. A wide range of time to detection (1-253 days) and non-specific symptoms suggest hyponatraemia is detected by chance rather than being specifically looked for. This is probably a sporadic, idiosyncratic phenomenon that is not dose related as A VP function determined by serum and urine concentrations was found to be normal in six elderly patients using sertraline. In the elderly there are physiological changes, a high prevalence of medical illnesses and concomitant drug use which may precipitate hyponatraemia. Together with a risk of altered water regulation in psychiatric illness this may account for the particular susceptibility of this group to hyponatraemia whilst using SSRis. AIMS & HYPOTHESIS: This dissertation will explore the physiology of Arginine V asopressin and how changes in this system along with other physiological changes in the elderly make the elderly susceptible to hyponatraemia. This problem will then be explored in the context of elderly people with depression using SSRis which are known to cause hyponatraemia. In the first part of the research section the aims are to report the published cases of hyponatraemia occurring whilst using SSRis from the United Kingdom and specifically focus on cases in people 60 years and older. Secondly to re-analyse all case reports in the literature looking only at this population. The third aim was to investigate whether dysregulation of vasopressin function in the elderly using SSRis is a sporadic or usual phenomenon. The null hypothesis is that A VP function is not disturbed by SSRis. 2017-11-15T07:46:47Z 2017-11-15T07:46:47Z 1999 2017-04-03T14:22:55Z Master Thesis Masters MMed http://hdl.handle.net/11427/26271 eng application/pdf Department of Psychiatry and Mental Health Faculty of Health Sciences University of Cape Town |
| spellingShingle | Hyponatraemia Psychiatry Kirchner, Vincent The elderly, arginine vasopressin & selective serotonin reuptake inhibitors |
| thesis_degree_str | Master's |
| title | The elderly, arginine vasopressin & selective serotonin reuptake inhibitors |
| title_full | The elderly, arginine vasopressin & selective serotonin reuptake inhibitors |
| title_fullStr | The elderly, arginine vasopressin & selective serotonin reuptake inhibitors |
| title_full_unstemmed | The elderly, arginine vasopressin & selective serotonin reuptake inhibitors |
| title_short | The elderly, arginine vasopressin & selective serotonin reuptake inhibitors |
| title_sort | elderly arginine vasopressin amp selective serotonin reuptake inhibitors |
| topic | Hyponatraemia Psychiatry |
| url | http://hdl.handle.net/11427/26271 |
| work_keys_str_mv | AT kirchnervincent theelderlyargininevasopressinampselectiveserotoninreuptakeinhibitors AT kirchnervincent elderlyargininevasopressinampselectiveserotoninreuptakeinhibitors |