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A study of the teratogenicity of diphenylhydantoin and phenobarbitone in the experimental mouse
The aims of the research were to establish whether diphenylhydantoin and phenobarbitone are teratogenic in mice both in vivo and in an in vitro whole embryo culture system, to investigate possible mechanisms of teratogenicity and to examine whether the methods used in this study, may form a basis fo...
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Clinical Pharmacology
2017
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| _version_ | 1867613956157210624 |
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| access_status_str | Open Access |
| author | Beyers, Nulda |
| author2 | Folb, Peter I |
| author_browse | Beyers, Nulda Folb, Peter I |
| author_facet | Folb, Peter I Beyers, Nulda |
| author_sort | Beyers, Nulda |
| collection | Thesis |
| description | The aims of the research were to establish whether diphenylhydantoin and phenobarbitone are teratogenic in mice both in vivo and in an in vitro whole embryo culture system, to investigate possible mechanisms of teratogenicity and to examine whether the methods used in this study, may form a basis for developing systems of more extensive drug teratogenicity screening. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/26474 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:44:22.948Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Division of Clinical Pharmacology |
| publisherStr | Division of Clinical Pharmacology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/26474 A study of the teratogenicity of diphenylhydantoin and phenobarbitone in the experimental mouse Beyers, Nulda Folb, Peter I Abnormalities, Drug-induced Foetus - Drug effects Phenobarbital - adverse effects Teratogens The aims of the research were to establish whether diphenylhydantoin and phenobarbitone are teratogenic in mice both in vivo and in an in vitro whole embryo culture system, to investigate possible mechanisms of teratogenicity and to examine whether the methods used in this study, may form a basis for developing systems of more extensive drug teratogenicity screening. 2017-12-07T06:18:26Z 2017-12-07T06:18:26Z 1981 2017-08-04T08:49:19Z Master Thesis Masters MSc http://hdl.handle.net/11427/26474 eng application/pdf Division of Clinical Pharmacology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Abnormalities, Drug-induced Foetus - Drug effects Phenobarbital - adverse effects Teratogens Beyers, Nulda A study of the teratogenicity of diphenylhydantoin and phenobarbitone in the experimental mouse |
| thesis_degree_str | Master's |
| title | A study of the teratogenicity of diphenylhydantoin and phenobarbitone in the experimental mouse |
| title_full | A study of the teratogenicity of diphenylhydantoin and phenobarbitone in the experimental mouse |
| title_fullStr | A study of the teratogenicity of diphenylhydantoin and phenobarbitone in the experimental mouse |
| title_full_unstemmed | A study of the teratogenicity of diphenylhydantoin and phenobarbitone in the experimental mouse |
| title_short | A study of the teratogenicity of diphenylhydantoin and phenobarbitone in the experimental mouse |
| title_sort | study of the teratogenicity of diphenylhydantoin and phenobarbitone in the experimental mouse |
| topic | Abnormalities, Drug-induced Foetus - Drug effects Phenobarbital - adverse effects Teratogens |
| url | http://hdl.handle.net/11427/26474 |
| work_keys_str_mv | AT beyersnulda astudyoftheteratogenicityofdiphenylhydantoinandphenobarbitoneintheexperimentalmouse AT beyersnulda studyoftheteratogenicityofdiphenylhydantoinandphenobarbitoneintheexperimentalmouse |