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A descriptive study of IgG subclasses and allotypes in children with pulmonary tuberculosis in the Western Cape

STUDY OBJECTIVES: An analysis of IgG subclasses and allotypes in children with pulmonary Tuberculosis (PTB) in the Western Cape. DESIGN: Consecutive children under 15 years of age with microbiological proven PTB over an 8 month period- November 1993 to July 1994. SETTING: Teaching Hospitals in Cape...

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Main Author: Potgieter, Stephanus Theron
Other Authors: Beatty, David William
Format: Thesis
Language:English
Published: Division of Pulmonology 2017
Subjects:
Pulmonary Tuberculosis
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access_status_str Open Access
author Potgieter, Stephanus Theron
author2 Beatty, David William
author_browse Beatty, David William
Potgieter, Stephanus Theron
author_facet Beatty, David William
Potgieter, Stephanus Theron
author_sort Potgieter, Stephanus Theron
collection Thesis
description STUDY OBJECTIVES: An analysis of IgG subclasses and allotypes in children with pulmonary Tuberculosis (PTB) in the Western Cape. DESIGN: Consecutive children under 15 years of age with microbiological proven PTB over an 8 month period- November 1993 to July 1994. SETTING: Teaching Hospitals in Cape Town. PATIENTS: Thirty-five cases were selected from 99 consecutive cases that were Mycobacterium tuberculosis positive, 15 of which were of Mixed and 20 were of Black Ancestry. CONTROL GROUP: Sera were selected from 224 Black Ancestry (59 children and 165 adults) and 211 Mixed Ancestry (67 children and 144 adults) that had no evidence for active tuberculosis or a history of previous TB diagnosis. MEASUREMENTS AND RESULTS: IgG subclasses, total IgG,and five allotypes: Glm(a), Glm(f), G2m(n), G3m(bl), G3m(gl) were determined by ELISA techniques. In the Mixed ancestry group the Glm(f) (p= 0.01), G2m(n) (p= 0.04) and G3m(gl) (p=0.001) allotypes were less frequently found in children with proven PTB. In the Black Ancestry subjects the G3m(g 1) allotype was significantly less common than in the control group (p < 0.001). CONCLUSIONS: Because allotypes are inherited in a Mendelian fashion, the observed association of childhood PTB and certain allotypes strengthens the hypothesis that a genetic susceptibility exists to acquiring TB.
format Thesis
id oai:open.uct.ac.za:11427/26487
institution University of Cape Town (South Africa)
language eng
last_indexed 2026-06-10T12:32:51.499Z
license_str Not specified — see source repository
provenance_str_mv Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository
publishDate 2017
publishDateRange 2017
publishDateSort 2017
publisher Division of Pulmonology
publisherStr Division of Pulmonology
record_format dspace
source_str UCTD — University of Cape Town Open Access Repository
spelling oai:open.uct.ac.za:11427/26487 A descriptive study of IgG subclasses and allotypes in children with pulmonary tuberculosis in the Western Cape Potgieter, Stephanus Theron Beatty, David William Pulmonary Tuberculosis STUDY OBJECTIVES: An analysis of IgG subclasses and allotypes in children with pulmonary Tuberculosis (PTB) in the Western Cape. DESIGN: Consecutive children under 15 years of age with microbiological proven PTB over an 8 month period- November 1993 to July 1994. SETTING: Teaching Hospitals in Cape Town. PATIENTS: Thirty-five cases were selected from 99 consecutive cases that were Mycobacterium tuberculosis positive, 15 of which were of Mixed and 20 were of Black Ancestry. CONTROL GROUP: Sera were selected from 224 Black Ancestry (59 children and 165 adults) and 211 Mixed Ancestry (67 children and 144 adults) that had no evidence for active tuberculosis or a history of previous TB diagnosis. MEASUREMENTS AND RESULTS: IgG subclasses, total IgG,and five allotypes: Glm(a), Glm(f), G2m(n), G3m(bl), G3m(gl) were determined by ELISA techniques. In the Mixed ancestry group the Glm(f) (p= 0.01), G2m(n) (p= 0.04) and G3m(gl) (p=0.001) allotypes were less frequently found in children with proven PTB. In the Black Ancestry subjects the G3m(g 1) allotype was significantly less common than in the control group (p < 0.001). CONCLUSIONS: Because allotypes are inherited in a Mendelian fashion, the observed association of childhood PTB and certain allotypes strengthens the hypothesis that a genetic susceptibility exists to acquiring TB. 2017-12-07T08:44:52Z 2017-12-07T08:44:52Z 1997 2017-08-17T13:43:34Z Master Thesis Masters MMed http://hdl.handle.net/11427/26487 eng application/pdf Division of Pulmonology Faculty of Health Sciences University of Cape Town
spellingShingle Pulmonary Tuberculosis
Potgieter, Stephanus Theron
A descriptive study of IgG subclasses and allotypes in children with pulmonary tuberculosis in the Western Cape
thesis_degree_str Master's
title A descriptive study of IgG subclasses and allotypes in children with pulmonary tuberculosis in the Western Cape
title_full A descriptive study of IgG subclasses and allotypes in children with pulmonary tuberculosis in the Western Cape
title_fullStr A descriptive study of IgG subclasses and allotypes in children with pulmonary tuberculosis in the Western Cape
title_full_unstemmed A descriptive study of IgG subclasses and allotypes in children with pulmonary tuberculosis in the Western Cape
title_short A descriptive study of IgG subclasses and allotypes in children with pulmonary tuberculosis in the Western Cape
title_sort descriptive study of igg subclasses and allotypes in children with pulmonary tuberculosis in the western cape
topic Pulmonary Tuberculosis
url http://hdl.handle.net/11427/26487
work_keys_str_mv AT potgieterstephanustheron adescriptivestudyofiggsubclassesandallotypesinchildrenwithpulmonarytuberculosisinthewesterncape
AT potgieterstephanustheron descriptivestudyofiggsubclassesandallotypesinchildrenwithpulmonarytuberculosisinthewesterncape

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