Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
The role of endotoxin receptors toll-like receptor 4 and lipopolysaccharide-binding protein in Mycobacterium tuberculosis infection
The aim of this study was to investigate the role of PRRs, namely TLR4 and LBP in vivo in the development of an immune response to a Mycobacterium tuberculosis infection. Mice with null mutations of the endotoxin receptors LBP and TLR4 were compared with wild-type mice (PRRs intact) in the context o...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Immunology
2017
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613235420594176 |
|---|---|
| access_status_str | Open Access |
| author | Abel, Brain |
| author2 | Ryffel, Bernhard |
| author_browse | Abel, Brain Ryffel, Bernhard |
| author_facet | Ryffel, Bernhard Abel, Brain |
| author_sort | Abel, Brain |
| collection | Thesis |
| description | The aim of this study was to investigate the role of PRRs, namely TLR4 and LBP in vivo in the development of an immune response to a Mycobacterium tuberculosis infection. Mice with null mutations of the endotoxin receptors LBP and TLR4 were compared with wild-type mice (PRRs intact) in the context of an aerosol Mtb infection. The following questions were posed: Are the PRR-disrupted animals more susceptible to M.tuberculosis infection? What role do these PRRs play in inflammatory processes and in the development of granuloma? What role do the PRRs play in driving cytokine and chemokine response? Specifically, the following mice were infected aerogenically with Mtb H37Rv to further investigate their roles in vivo in mounting an effective immune response: C3H/HeN and C3H/ HeJ (TLR4 mutant) LBP+/+ and LBP-/- |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/26514 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:54.720Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Division of Immunology |
| publisherStr | Division of Immunology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/26514 The role of endotoxin receptors toll-like receptor 4 and lipopolysaccharide-binding protein in Mycobacterium tuberculosis infection Abel, Brain Ryffel, Bernhard Immunology The aim of this study was to investigate the role of PRRs, namely TLR4 and LBP in vivo in the development of an immune response to a Mycobacterium tuberculosis infection. Mice with null mutations of the endotoxin receptors LBP and TLR4 were compared with wild-type mice (PRRs intact) in the context of an aerosol Mtb infection. The following questions were posed: Are the PRR-disrupted animals more susceptible to M.tuberculosis infection? What role do these PRRs play in inflammatory processes and in the development of granuloma? What role do the PRRs play in driving cytokine and chemokine response? Specifically, the following mice were infected aerogenically with Mtb H37Rv to further investigate their roles in vivo in mounting an effective immune response: C3H/HeN and C3H/ HeJ (TLR4 mutant) LBP+/+ and LBP-/- 2017-12-08T13:56:14Z 2017-12-08T13:56:14Z 2002 Master Thesis Masters MSc (Med) http://hdl.handle.net/11427/26514 eng application/pdf Division of Immunology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Immunology Abel, Brain The role of endotoxin receptors toll-like receptor 4 and lipopolysaccharide-binding protein in Mycobacterium tuberculosis infection |
| thesis_degree_str | Master's |
| title | The role of endotoxin receptors toll-like receptor 4 and lipopolysaccharide-binding protein in Mycobacterium tuberculosis infection |
| title_full | The role of endotoxin receptors toll-like receptor 4 and lipopolysaccharide-binding protein in Mycobacterium tuberculosis infection |
| title_fullStr | The role of endotoxin receptors toll-like receptor 4 and lipopolysaccharide-binding protein in Mycobacterium tuberculosis infection |
| title_full_unstemmed | The role of endotoxin receptors toll-like receptor 4 and lipopolysaccharide-binding protein in Mycobacterium tuberculosis infection |
| title_short | The role of endotoxin receptors toll-like receptor 4 and lipopolysaccharide-binding protein in Mycobacterium tuberculosis infection |
| title_sort | role of endotoxin receptors toll like receptor 4 and lipopolysaccharide binding protein in mycobacterium tuberculosis infection |
| topic | Immunology |
| url | http://hdl.handle.net/11427/26514 |
| work_keys_str_mv | AT abelbrain theroleofendotoxinreceptorstolllikereceptor4andlipopolysaccharidebindingproteininmycobacteriumtuberculosisinfection AT abelbrain roleofendotoxinreceptorstolllikereceptor4andlipopolysaccharidebindingproteininmycobacteriumtuberculosisinfection |