Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
The test meal and exocrine pancreatic function
The pancreas is a very inaccessible organ situated in the retroperitoneal space. Study of its physiology and function was first confined to animals, where it was possible to construct a pancreatic fistula and thus collect pure pancreatic juice. In addition, pancreatic tissue from animals was also ob...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Human Nutrition
2017
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613340524609536 |
|---|---|
| access_status_str | Open Access |
| author | Brom, Bernard |
| author2 | Bank, S |
| author_browse | Bank, S Brom, Bernard |
| author_facet | Bank, S Brom, Bernard |
| author_sort | Brom, Bernard |
| collection | Thesis |
| description | The pancreas is a very inaccessible organ situated in the retroperitoneal space. Study of its physiology and function was first confined to animals, where it was possible to construct a pancreatic fistula and thus collect pure pancreatic juice. In addition, pancreatic tissue from animals was also obtainable relatively easily. Early attempts to study the pancreas in man was restricted to patients with pancreatic fistulae, usually the result of surgical procedures. These investigations were on the whole unsatisfactory as the conditions of the experiment were not truly physiological and the juice soon became contaminated and infected. Another method employed later used the intraduodenal tube to collect duodenal contents. The aspirate consisted of a mixture of gastric acid and contents, duodenal juice, bile and succus entericus. Various meals were used to stimulate the pancreatic secretion. Other authors have emphasized the importance of preventing contamination of duodenal contents with gastric juice, and by inserting a second tube or double lumen tube to aspirate the acid from the stomach this was attained. Meal stimulation was now no longer possible so that various drugs and later the two hormones, secretin and pancreozymin, were used to stimulate pancreatic secretion. These two hormones very soon completely replaced any other method of pancreatic simulation. The intravenous injection or infusion of secretin and/or pancreozymin is, however, not a physiological procedure. The initial enthusiasm aroused by this method was tempered due to the varied results obtained by different workers. More recently, Lund has used the test meal to stimulate pancreatic secretion. This technique has been replicated by numerous authors, with promising results reported by all. These reports are characterized by the varied nature of the test meal used, the different position of the intraduodenal tube, the type of suction employed, the period of collection, the length of the test and the type of enzymes estimated. The purpose of the present study is to investigate the physiological responses to the test meal, to define its value in the investigation of pancreatic function and to try and standardise the procedure to obtain optimal pancreatic stimulation. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/26522 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:33.896Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Division of Human Nutrition |
| publisherStr | Division of Human Nutrition |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/26522 The test meal and exocrine pancreatic function Brom, Bernard Bank, S Pancreatic function The pancreas is a very inaccessible organ situated in the retroperitoneal space. Study of its physiology and function was first confined to animals, where it was possible to construct a pancreatic fistula and thus collect pure pancreatic juice. In addition, pancreatic tissue from animals was also obtainable relatively easily. Early attempts to study the pancreas in man was restricted to patients with pancreatic fistulae, usually the result of surgical procedures. These investigations were on the whole unsatisfactory as the conditions of the experiment were not truly physiological and the juice soon became contaminated and infected. Another method employed later used the intraduodenal tube to collect duodenal contents. The aspirate consisted of a mixture of gastric acid and contents, duodenal juice, bile and succus entericus. Various meals were used to stimulate the pancreatic secretion. Other authors have emphasized the importance of preventing contamination of duodenal contents with gastric juice, and by inserting a second tube or double lumen tube to aspirate the acid from the stomach this was attained. Meal stimulation was now no longer possible so that various drugs and later the two hormones, secretin and pancreozymin, were used to stimulate pancreatic secretion. These two hormones very soon completely replaced any other method of pancreatic simulation. The intravenous injection or infusion of secretin and/or pancreozymin is, however, not a physiological procedure. The initial enthusiasm aroused by this method was tempered due to the varied results obtained by different workers. More recently, Lund has used the test meal to stimulate pancreatic secretion. This technique has been replicated by numerous authors, with promising results reported by all. These reports are characterized by the varied nature of the test meal used, the different position of the intraduodenal tube, the type of suction employed, the period of collection, the length of the test and the type of enzymes estimated. The purpose of the present study is to investigate the physiological responses to the test meal, to define its value in the investigation of pancreatic function and to try and standardise the procedure to obtain optimal pancreatic stimulation. 2017-12-11T10:15:08Z 2017-12-11T10:15:08Z 1969 Doctoral Thesis Doctoral MD http://hdl.handle.net/11427/26522 eng application/pdf Division of Human Nutrition Faculty of Health Sciences University of Cape Town |
| spellingShingle | Pancreatic function Brom, Bernard The test meal and exocrine pancreatic function |
| thesis_degree_str | Doctoral |
| title | The test meal and exocrine pancreatic function |
| title_full | The test meal and exocrine pancreatic function |
| title_fullStr | The test meal and exocrine pancreatic function |
| title_full_unstemmed | The test meal and exocrine pancreatic function |
| title_short | The test meal and exocrine pancreatic function |
| title_sort | test meal and exocrine pancreatic function |
| topic | Pancreatic function |
| url | http://hdl.handle.net/11427/26522 |
| work_keys_str_mv | AT brombernard thetestmealandexocrinepancreaticfunction AT brombernard testmealandexocrinepancreaticfunction |