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Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide
Pancreatic polypeptide (PP) is a 36 amino-acid residue peptide which has recently been recognised in pancreatic endocrine cells. Although PP has a number of effects on gastrointestinal and pancreatic exocrine function, its physiological function has not been clarified. Studies were undertaken to elu...
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| Format: | Thesis |
| Language: | English |
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Division of Endocrinology and Diabetology
2017
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| _version_ | 1867613140267565056 |
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| access_status_str | Open Access |
| author | Sive, Alan Avrom |
| author2 | Vinik, A I |
| author_browse | Sive, Alan Avrom Vinik, A I |
| author_facet | Vinik, A I Sive, Alan Avrom |
| author_sort | Sive, Alan Avrom |
| collection | Thesis |
| description | Pancreatic polypeptide (PP) is a 36 amino-acid residue peptide which has recently been recognised in pancreatic endocrine cells. Although PP has a number of effects on gastrointestinal and pancreatic exocrine function, its physiological function has not been clarified. Studies were undertaken to elucidate four aspects of the physiology and pathophysiology of this candidate hormone. Firstly, factors affecting the release of human PP (hPP) were assessed in healthy subjects; secondly polyacrylamide gel electrophoresis was used to investigate molecular heterogeneity of the peptide; thirdly, the organ uptake and half-life time of endogenous PP was measured in pigs; and finally, basal and stimulated serum hPP concentrations were assayed in patients with acute pancreatitis, chronic pancreatitis and maturity-onset diabetes mellitus. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/26525 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:24.573Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Division of Endocrinology and Diabetology |
| publisherStr | Division of Endocrinology and Diabetology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/26525 Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide Sive, Alan Avrom Vinik, A I Diabetology Pancreatic polypeptide (PP) is a 36 amino-acid residue peptide which has recently been recognised in pancreatic endocrine cells. Although PP has a number of effects on gastrointestinal and pancreatic exocrine function, its physiological function has not been clarified. Studies were undertaken to elucidate four aspects of the physiology and pathophysiology of this candidate hormone. Firstly, factors affecting the release of human PP (hPP) were assessed in healthy subjects; secondly polyacrylamide gel electrophoresis was used to investigate molecular heterogeneity of the peptide; thirdly, the organ uptake and half-life time of endogenous PP was measured in pigs; and finally, basal and stimulated serum hPP concentrations were assayed in patients with acute pancreatitis, chronic pancreatitis and maturity-onset diabetes mellitus. 2017-12-11T10:15:53Z 2017-12-11T10:15:53Z 1982 Doctoral Thesis Doctoral MD http://hdl.handle.net/11427/26525 eng application/pdf Division of Endocrinology and Diabetology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Diabetology Sive, Alan Avrom Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide |
| thesis_degree_str | Doctoral |
| title | Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide |
| title_full | Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide |
| title_fullStr | Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide |
| title_full_unstemmed | Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide |
| title_short | Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide |
| title_sort | studies on aspects of the physiology and pathophysiology of pancreatic polypeptide |
| topic | Diabetology |
| url | http://hdl.handle.net/11427/26525 |
| work_keys_str_mv | AT sivealanavrom studiesonaspectsofthephysiologyandpathophysiologyofpancreaticpolypeptide |