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Factors limiting the exercise tolerance of patients with end-stage renal failure undergoing maintenance haemodialysis
Exercise tolerance, measured as peak oxygen consumption (VO₂ peak), is very low in patients with end-stage renal failure undergoing maintenance haemodialysis. Due to their associated anaemia and low peak heart rates during maximal exercise it has been argued that the reduced blood oxygen carrying ca...
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| Format: | Thesis |
| Language: | English |
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MRC/UCT RU for Exercise and Sport Medicine
2017
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| _version_ | 1867613149210869760 |
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| access_status_str | Open Access |
| author | Diesel, Wayne Jonathan |
| author2 | Noakes, Timothy D |
| author_browse | Diesel, Wayne Jonathan Noakes, Timothy D |
| author_facet | Noakes, Timothy D Diesel, Wayne Jonathan |
| author_sort | Diesel, Wayne Jonathan |
| collection | Thesis |
| description | Exercise tolerance, measured as peak oxygen consumption (VO₂ peak), is very low in patients with end-stage renal failure undergoing maintenance haemodialysis. Due to their associated anaemia and low peak heart rates during maximal exercise it has been argued that the reduced blood oxygen carrying capacity and central cardiovascular limitations are primarily responsible for the poor exercise tolerance of these patients. However, others suggest that peripheral (skeletal muscle) limitations including impaired substrate utilization, muscle weakness caused by peripheral neuropathy and myopathy, malnutrition and general physical deconditioning are responsible for the poor exercise tolerance. The present thesis was therefore designed to study whether central cardiovascular function or anaemia or muscle weakness causes patients with end-stage renal failure to terminate exercise at workrates well below those achieved by healthy controls. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/26548 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:31.816Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | MRC/UCT RU for Exercise and Sport Medicine |
| publisherStr | MRC/UCT RU for Exercise and Sport Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/26548 Factors limiting the exercise tolerance of patients with end-stage renal failure undergoing maintenance haemodialysis Diesel, Wayne Jonathan Noakes, Timothy D Exercise Tolerance - physiology Kidney failure, Chronic - Physiopathology Hemodialysis Medical Physiology Exercise tolerance, measured as peak oxygen consumption (VO₂ peak), is very low in patients with end-stage renal failure undergoing maintenance haemodialysis. Due to their associated anaemia and low peak heart rates during maximal exercise it has been argued that the reduced blood oxygen carrying capacity and central cardiovascular limitations are primarily responsible for the poor exercise tolerance of these patients. However, others suggest that peripheral (skeletal muscle) limitations including impaired substrate utilization, muscle weakness caused by peripheral neuropathy and myopathy, malnutrition and general physical deconditioning are responsible for the poor exercise tolerance. The present thesis was therefore designed to study whether central cardiovascular function or anaemia or muscle weakness causes patients with end-stage renal failure to terminate exercise at workrates well below those achieved by healthy controls. 2017-12-11T14:14:28Z 2017-12-11T14:14:28Z 1994 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/26548 eng application/pdf MRC/UCT RU for Exercise and Sport Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Exercise Tolerance - physiology Kidney failure, Chronic - Physiopathology Hemodialysis Medical Physiology Diesel, Wayne Jonathan Factors limiting the exercise tolerance of patients with end-stage renal failure undergoing maintenance haemodialysis |
| thesis_degree_str | Doctoral |
| title | Factors limiting the exercise tolerance of patients with end-stage renal failure undergoing maintenance haemodialysis |
| title_full | Factors limiting the exercise tolerance of patients with end-stage renal failure undergoing maintenance haemodialysis |
| title_fullStr | Factors limiting the exercise tolerance of patients with end-stage renal failure undergoing maintenance haemodialysis |
| title_full_unstemmed | Factors limiting the exercise tolerance of patients with end-stage renal failure undergoing maintenance haemodialysis |
| title_short | Factors limiting the exercise tolerance of patients with end-stage renal failure undergoing maintenance haemodialysis |
| title_sort | factors limiting the exercise tolerance of patients with end stage renal failure undergoing maintenance haemodialysis |
| topic | Exercise Tolerance - physiology Kidney failure, Chronic - Physiopathology Hemodialysis Medical Physiology |
| url | http://hdl.handle.net/11427/26548 |
| work_keys_str_mv | AT dieselwaynejonathan factorslimitingtheexercisetoleranceofpatientswithendstagerenalfailureundergoingmaintenancehaemodialysis |