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The effect of muscle glycogen status on control of substrate metabolism during exercise
Glycogen depletion has frequently been shown to result in a decrease in respiratory exchange ratio (RER). However, the metabolic response to glycogen depletion has generally been studied in overnight fasted subjects or in subjects who were already fatigued, or hypoglycaemic, or both, raising the que...
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| Format: | Thesis |
| Language: | English |
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MRC/UCT RU for Exercise and Sport Medicine
2017
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| _version_ | 1867614014273486848 |
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| access_status_str | Open Access |
| author | Weltan, Sandra Mary |
| author2 | Noakes, Timothy D |
| author_browse | Noakes, Timothy D Weltan, Sandra Mary |
| author_facet | Noakes, Timothy D Weltan, Sandra Mary |
| author_sort | Weltan, Sandra Mary |
| collection | Thesis |
| description | Glycogen depletion has frequently been shown to result in a decrease in respiratory exchange ratio (RER). However, the metabolic response to glycogen depletion has generally been studied in overnight fasted subjects or in subjects who were already fatigued, or hypoglycaemic, or both, raising the question of whether the differences seen were due to general "carbohydrate deficiency" or due specifically to muscle or liver glycogen depletion. If euglycaemia and especially hyperglycaemia is maintained, the " carbohydrate deficiency" is overcome. In addition, because insulin stimulates muscle glucose uptake and not liver glucose uptake during euglycaemia (except at very high concentrations), insulin infusion would differentiate between liver and muscle glycogen depletion, since if the decrease in RER previously observed is abolished with insulin infusion while euglycaemia is maintained, this would indicate that the decrease is specifically due to muscle glycogen depletion. Thus, the aim of this study was to investigate the metabolic effect of glycogen content while an adequate amount or an excess of carbohydrate was provided in the form of an intravenous glucose infusion and when plasma insulin concentrations are raised. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/26559 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:45:18.373Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | MRC/UCT RU for Exercise and Sport Medicine |
| publisherStr | MRC/UCT RU for Exercise and Sport Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/26559 The effect of muscle glycogen status on control of substrate metabolism during exercise Weltan, Sandra Mary Noakes, Timothy D Dennis, Steve Medical Physiology Exercise Science Glycogen depletion has frequently been shown to result in a decrease in respiratory exchange ratio (RER). However, the metabolic response to glycogen depletion has generally been studied in overnight fasted subjects or in subjects who were already fatigued, or hypoglycaemic, or both, raising the question of whether the differences seen were due to general "carbohydrate deficiency" or due specifically to muscle or liver glycogen depletion. If euglycaemia and especially hyperglycaemia is maintained, the " carbohydrate deficiency" is overcome. In addition, because insulin stimulates muscle glucose uptake and not liver glucose uptake during euglycaemia (except at very high concentrations), insulin infusion would differentiate between liver and muscle glycogen depletion, since if the decrease in RER previously observed is abolished with insulin infusion while euglycaemia is maintained, this would indicate that the decrease is specifically due to muscle glycogen depletion. Thus, the aim of this study was to investigate the metabolic effect of glycogen content while an adequate amount or an excess of carbohydrate was provided in the form of an intravenous glucose infusion and when plasma insulin concentrations are raised. 2017-12-12T10:55:58Z 2017-12-12T10:55:58Z 1998 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/26559 eng application/pdf MRC/UCT RU for Exercise and Sport Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Physiology Exercise Science Weltan, Sandra Mary The effect of muscle glycogen status on control of substrate metabolism during exercise |
| thesis_degree_str | Doctoral |
| title | The effect of muscle glycogen status on control of substrate metabolism during exercise |
| title_full | The effect of muscle glycogen status on control of substrate metabolism during exercise |
| title_fullStr | The effect of muscle glycogen status on control of substrate metabolism during exercise |
| title_full_unstemmed | The effect of muscle glycogen status on control of substrate metabolism during exercise |
| title_short | The effect of muscle glycogen status on control of substrate metabolism during exercise |
| title_sort | effect of muscle glycogen status on control of substrate metabolism during exercise |
| topic | Medical Physiology Exercise Science |
| url | http://hdl.handle.net/11427/26559 |
| work_keys_str_mv | AT weltansandramary theeffectofmuscleglycogenstatusoncontrolofsubstratemetabolismduringexercise AT weltansandramary effectofmuscleglycogenstatusoncontrolofsubstratemetabolismduringexercise |