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A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga
Following the completion of a detailed baseline study of malaria in the region, a model was developed to assess the cost-effectiveness of switching from chloroquine to sulfadoxine-pyrimetharnine as first line treatment in the Tonga district of Mpumalanga, South Africa, where malaria is seasonal and...
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| Format: | Thesis |
| Language: | English |
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Division of Clinical Pharmacology
2018
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| _version_ | 1867614368819052544 |
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| access_status_str | Open Access |
| author | Wilkins, Justin |
| author2 | Barnes, Karen I |
| author_browse | Barnes, Karen I Wilkins, Justin |
| author_facet | Barnes, Karen I Wilkins, Justin |
| author_sort | Wilkins, Justin |
| collection | Thesis |
| description | Following the completion of a detailed baseline study of malaria in the region, a model was developed to assess the cost-effectiveness of switching from chloroquine to sulfadoxine-pyrimetharnine as first line treatment in the Tonga district of Mpumalanga, South Africa, where malaria is seasonal and the population is non-immune. In vivo drug resistance was used to create a resistance variable, which was used to assess the 1997 relative costs to the health care system of employing the two drugs, analysing factors such as drug costs, staff time, transport costs, maintenance costs, utility costs, training costs and consumables costs to generate an average cost-effectiveness ratio. The model was subsequently used to estimate the average cost-effectiveness ratios of nine other potential agents for the treatment of first line malaria, including artesunate monotherapy, artesunate combinations, pyronaridine, atovaquone-proguanil, co-artemether, halofantrine, amodiaquine, and mefloquine. It was found that sulfadoxinepyrimethamine was 5 times more cost-effective as first line therapy than chloroquine. Of the other modelled drugs, it was recommended that an artesunate combination should be implemented when it becomes necessary to replace sulfadoxine-pyrimethamine; artesunate-mefloquine and artesunate-SP were estimated to be 6 times and 9 times as cost-effective as chloroquine, respectively. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/26763 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:50:56.494Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Division of Clinical Pharmacology |
| publisherStr | Division of Clinical Pharmacology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/26763 A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga Wilkins, Justin Barnes, Karen I Folb, Peter I Pharmacology Following the completion of a detailed baseline study of malaria in the region, a model was developed to assess the cost-effectiveness of switching from chloroquine to sulfadoxine-pyrimetharnine as first line treatment in the Tonga district of Mpumalanga, South Africa, where malaria is seasonal and the population is non-immune. In vivo drug resistance was used to create a resistance variable, which was used to assess the 1997 relative costs to the health care system of employing the two drugs, analysing factors such as drug costs, staff time, transport costs, maintenance costs, utility costs, training costs and consumables costs to generate an average cost-effectiveness ratio. The model was subsequently used to estimate the average cost-effectiveness ratios of nine other potential agents for the treatment of first line malaria, including artesunate monotherapy, artesunate combinations, pyronaridine, atovaquone-proguanil, co-artemether, halofantrine, amodiaquine, and mefloquine. It was found that sulfadoxinepyrimethamine was 5 times more cost-effective as first line therapy than chloroquine. Of the other modelled drugs, it was recommended that an artesunate combination should be implemented when it becomes necessary to replace sulfadoxine-pyrimethamine; artesunate-mefloquine and artesunate-SP were estimated to be 6 times and 9 times as cost-effective as chloroquine, respectively. 2018-01-09T08:57:37Z 2018-01-09T08:57:37Z 1999 Master Thesis Masters MSc (Med) http://hdl.handle.net/11427/26763 eng application/pdf Division of Clinical Pharmacology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Pharmacology Wilkins, Justin A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga |
| thesis_degree_str | Master's |
| title | A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga |
| title_full | A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga |
| title_fullStr | A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga |
| title_full_unstemmed | A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga |
| title_short | A cost analysis of the treatment of first-line uncomplicated malaria in the Tonga district of Mpumalanga |
| title_sort | cost analysis of the treatment of first line uncomplicated malaria in the tonga district of mpumalanga |
| topic | Pharmacology |
| url | http://hdl.handle.net/11427/26763 |
| work_keys_str_mv | AT wilkinsjustin acostanalysisofthetreatmentoffirstlineuncomplicatedmalariainthetongadistrictofmpumalanga AT wilkinsjustin costanalysisofthetreatmentoffirstlineuncomplicatedmalariainthetongadistrictofmpumalanga |