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Screening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africa
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Chemical Pathology
2014
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| _version_ | 1867613173880717312 |
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| access_status_str | Open Access |
| author | Olufadi, Rasaq |
| author2 | Harley, Eric |
| author_browse | Harley, Eric Olufadi, Rasaq |
| author_facet | Harley, Eric Olufadi, Rasaq |
| author_sort | Olufadi, Rasaq |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/2698 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:56.645Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Chemical Pathology |
| publisherStr | Division of Chemical Pathology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/2698 Screening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africa Olufadi, Rasaq Harley, Eric Owen, E P Chemical Pathology Includes bibliographical references. Several studies have shown that patients with low TPMT activity are at risk for severe and potentially fatal haematopoietic toxicity when treated with conventional doses of thiopurine drugs. Genetic polymorphism in the TPMT gene is an important determinant of mercaptopurine toxicity. Patients with mutations in the TPMT gene have a less efficient methylation process, and are therefore, predisposed to severe myelosuppression. 2014-07-28T08:14:06Z 2014-07-28T08:14:06Z 2002 Master Thesis Masters MMed http://hdl.handle.net/11427/2698 eng application/pdf Division of Chemical Pathology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Chemical Pathology Olufadi, Rasaq Screening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africa |
| thesis_degree_str | Master's |
| title | Screening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africa |
| title_full | Screening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africa |
| title_fullStr | Screening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africa |
| title_full_unstemmed | Screening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africa |
| title_short | Screening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africa |
| title_sort | screening for thiopurine s methyltransferase tpmt gene mutations in south africa |
| topic | Chemical Pathology |
| url | http://hdl.handle.net/11427/2698 |
| work_keys_str_mv | AT olufadirasaq screeningforthiopurinesmethyltransferasetpmtgenemutationsinsouthafrica |