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Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity
The results of this study show that in intact rats magnesium produces a more rapid resolution of bupivacaine induced electrophysiological changes than placebo. The improvements are in rhythm and electrical conduction, although this is often at the expense of potentiating the bradycardic effects of b...
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| Format: | Thesis |
| Language: | English |
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Department of Anaesthesia
2018
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| _version_ | 1867613342375346176 |
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| access_status_str | Open Access |
| author | Reed, Anthony Raddon |
| author2 | James, Michael F M |
| author_browse | James, Michael F M Reed, Anthony Raddon |
| author_facet | James, Michael F M Reed, Anthony Raddon |
| author_sort | Reed, Anthony Raddon |
| collection | Thesis |
| description | The results of this study show that in intact rats magnesium produces a more rapid resolution of bupivacaine induced electrophysiological changes than placebo. The improvements are in rhythm and electrical conduction, although this is often at the expense of potentiating the bradycardic effects of bupivacaine toxicity. Whilst the bradycardia remains a problem it is potentially more amenable to therapy than the changes in rhythm and conduction which magnesium sulphate reversed. The opportunity therefore exists to explore the possibility of combining magnesium with a positive chronotrophic agent such as dobutamine. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/26985 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:36.552Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Department of Anaesthesia |
| publisherStr | Department of Anaesthesia |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/26985 Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity Reed, Anthony Raddon James, Michael F M Anaesthesia The results of this study show that in intact rats magnesium produces a more rapid resolution of bupivacaine induced electrophysiological changes than placebo. The improvements are in rhythm and electrical conduction, although this is often at the expense of potentiating the bradycardic effects of bupivacaine toxicity. Whilst the bradycardia remains a problem it is potentially more amenable to therapy than the changes in rhythm and conduction which magnesium sulphate reversed. The opportunity therefore exists to explore the possibility of combining magnesium with a positive chronotrophic agent such as dobutamine. 2018-01-25T13:57:23Z 2018-01-25T13:57:23Z 1998 Master Thesis Masters MMed http://hdl.handle.net/11427/26985 eng application/pdf Department of Anaesthesia Faculty of Health Sciences University of Cape Town |
| spellingShingle | Anaesthesia Reed, Anthony Raddon Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity |
| thesis_degree_str | Master's |
| title | Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity |
| title_full | Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity |
| title_fullStr | Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity |
| title_full_unstemmed | Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity |
| title_short | Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity |
| title_sort | magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity |
| topic | Anaesthesia |
| url | http://hdl.handle.net/11427/26985 |
| work_keys_str_mv | AT reedanthonyraddon magnesiumsulphatereversalofestablishedbupivacaineelectrophysiologicalcardiotoxicity |