Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
The diagnostic accuracy to Technetium 99m labelled erythrocyte scintigraphy in the investigation of hepatic mass lesions : special reference to hepatic cavernous haemangioma and hepatocellular carcinoma
The distinction between cavernous haemangiomas of the liver (which are the second most common hepatic mass lesions) from malignant lesions, is often difficult. An incorrect diagnosis of cavernous haemangioma, in a patient with malignancy, may adversely influence the outcome of subsequent treatment i...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Nuclear Medicine
2018
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613267231244288 |
|---|---|
| access_status_str | Open Access |
| author | Lourens, Steven |
| author2 | Mann, Michael D |
| author_browse | Lourens, Steven Mann, Michael D |
| author_facet | Mann, Michael D Lourens, Steven |
| author_sort | Lourens, Steven |
| collection | Thesis |
| description | The distinction between cavernous haemangiomas of the liver (which are the second most common hepatic mass lesions) from malignant lesions, is often difficult. An incorrect diagnosis of cavernous haemangioma, in a patient with malignancy, may adversely influence the outcome of subsequent treatment in these patients, due to delay in therapy. Although previous studies have suggested that ⁹⁹ᵐTc erythrocyte blood pool scintigraphy is both highly sensitive and specific for haemangiomas, a basic flaw in all previous studies has been the small number of control patients studied. Bayesian analysis clearly shows that specificity for a test is dependant on the pre-test probability of the lesion being present. Thus all the studies done to date, may reflect an inappropriately high specificity for ⁹⁹ᵐTc scintigraphy, in diagnosing cavernous haemangiomas, because they have mainly studied patients with haemangiomas and relatively few patients with other lesions. This study was thus undertaken to clarify the true accuracy of this technique, in distinguishing haemangiomas from other hepatic mass lesions, by studying a large number of patients with haemangiomas and other hepatic mass lesions. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/27037 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:25.185Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Division of Nuclear Medicine |
| publisherStr | Division of Nuclear Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/27037 The diagnostic accuracy to Technetium 99m labelled erythrocyte scintigraphy in the investigation of hepatic mass lesions : special reference to hepatic cavernous haemangioma and hepatocellular carcinoma Lourens, Steven Mann, Michael D Nuclear Medicine Carcinoma, Hepatocellular - radionuclide imaging Hemangioma, Cavernous - radionuclide imaging Radionuclide imaging - Methods Technetium - diagnostic use The distinction between cavernous haemangiomas of the liver (which are the second most common hepatic mass lesions) from malignant lesions, is often difficult. An incorrect diagnosis of cavernous haemangioma, in a patient with malignancy, may adversely influence the outcome of subsequent treatment in these patients, due to delay in therapy. Although previous studies have suggested that ⁹⁹ᵐTc erythrocyte blood pool scintigraphy is both highly sensitive and specific for haemangiomas, a basic flaw in all previous studies has been the small number of control patients studied. Bayesian analysis clearly shows that specificity for a test is dependant on the pre-test probability of the lesion being present. Thus all the studies done to date, may reflect an inappropriately high specificity for ⁹⁹ᵐTc scintigraphy, in diagnosing cavernous haemangiomas, because they have mainly studied patients with haemangiomas and relatively few patients with other lesions. This study was thus undertaken to clarify the true accuracy of this technique, in distinguishing haemangiomas from other hepatic mass lesions, by studying a large number of patients with haemangiomas and other hepatic mass lesions. 2018-01-29T06:48:06Z 2018-01-29T06:48:06Z 1995 Master Thesis Masters MMed http://hdl.handle.net/11427/27037 eng application/pdf Division of Nuclear Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Nuclear Medicine Carcinoma, Hepatocellular - radionuclide imaging Hemangioma, Cavernous - radionuclide imaging Radionuclide imaging - Methods Technetium - diagnostic use Lourens, Steven The diagnostic accuracy to Technetium 99m labelled erythrocyte scintigraphy in the investigation of hepatic mass lesions : special reference to hepatic cavernous haemangioma and hepatocellular carcinoma |
| thesis_degree_str | Master's |
| title | The diagnostic accuracy to Technetium 99m labelled erythrocyte scintigraphy in the investigation of hepatic mass lesions : special reference to hepatic cavernous haemangioma and hepatocellular carcinoma |
| title_full | The diagnostic accuracy to Technetium 99m labelled erythrocyte scintigraphy in the investigation of hepatic mass lesions : special reference to hepatic cavernous haemangioma and hepatocellular carcinoma |
| title_fullStr | The diagnostic accuracy to Technetium 99m labelled erythrocyte scintigraphy in the investigation of hepatic mass lesions : special reference to hepatic cavernous haemangioma and hepatocellular carcinoma |
| title_full_unstemmed | The diagnostic accuracy to Technetium 99m labelled erythrocyte scintigraphy in the investigation of hepatic mass lesions : special reference to hepatic cavernous haemangioma and hepatocellular carcinoma |
| title_short | The diagnostic accuracy to Technetium 99m labelled erythrocyte scintigraphy in the investigation of hepatic mass lesions : special reference to hepatic cavernous haemangioma and hepatocellular carcinoma |
| title_sort | diagnostic accuracy to technetium 99m labelled erythrocyte scintigraphy in the investigation of hepatic mass lesions special reference to hepatic cavernous haemangioma and hepatocellular carcinoma |
| topic | Nuclear Medicine Carcinoma, Hepatocellular - radionuclide imaging Hemangioma, Cavernous - radionuclide imaging Radionuclide imaging - Methods Technetium - diagnostic use |
| url | http://hdl.handle.net/11427/27037 |
| work_keys_str_mv | AT lourenssteven thediagnosticaccuracytotechnetium99mlabellederythrocytescintigraphyintheinvestigationofhepaticmasslesionsspecialreferencetohepaticcavernoushaemangiomaandhepatocellularcarcinoma AT lourenssteven diagnosticaccuracytotechnetium99mlabellederythrocytescintigraphyintheinvestigationofhepaticmasslesionsspecialreferencetohepaticcavernoushaemangiomaandhepatocellularcarcinoma |