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The investigation of the calcium antagonist nifedipine on fetal umbilical artery Doppler waveforms
The following thesis will describe the investigation of the effect of nifedipine (a calcium antagonist) on the Doppler flow velocity waveform of the umbilical artery. The thesis is divided into two parts. The first section is a literature review of the three main aspects of the thesis namely: 1. The...
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| Format: | Thesis |
| Language: | English |
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Department of Obstetrics and Gynaecology
2018
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| _version_ | 1867613162602233856 |
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| access_status_str | Open Access |
| author | Puzey, Martin Stanley |
| author2 | Lindow, Stephen |
| author_browse | Lindow, Stephen Puzey, Martin Stanley |
| author_facet | Lindow, Stephen Puzey, Martin Stanley |
| author_sort | Puzey, Martin Stanley |
| collection | Thesis |
| description | The following thesis will describe the investigation of the effect of nifedipine (a calcium antagonist) on the Doppler flow velocity waveform of the umbilical artery. The thesis is divided into two parts. The first section is a literature review of the three main aspects of the thesis namely: 1. The uteroplacental circulation in humans and the pathophysiology related to this circulation in hypertension and intrauterine growth retardation (IUGR). 2. The biokinetics of nifedipine and a review of the experiments that have been performed using the drug in human and animal models. 3. The principles of Doppler ultrasound and the literature pertaining to its use in the study of the uteroplacental circulation. The second part of the thesis is devoted to the effect of nifedipine on fetal umbilical artery Doppler waveform analysis. In the first ·stage of the investigation the effect of the drug on hypertensive mothers has been examined, and in the second stage the effect on fetuses that have an increased resistance index of the umbilical artery Doppler waveform. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/27134 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:45.395Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Department of Obstetrics and Gynaecology |
| publisherStr | Department of Obstetrics and Gynaecology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/27134 The investigation of the calcium antagonist nifedipine on fetal umbilical artery Doppler waveforms Puzey, Martin Stanley Lindow, Stephen Obstetrics and Gynaecology Ultrasonic imaging Nifedipine - pharmacology Umbilical Arteries - drug effects Ultrasonography, Prenatal The following thesis will describe the investigation of the effect of nifedipine (a calcium antagonist) on the Doppler flow velocity waveform of the umbilical artery. The thesis is divided into two parts. The first section is a literature review of the three main aspects of the thesis namely: 1. The uteroplacental circulation in humans and the pathophysiology related to this circulation in hypertension and intrauterine growth retardation (IUGR). 2. The biokinetics of nifedipine and a review of the experiments that have been performed using the drug in human and animal models. 3. The principles of Doppler ultrasound and the literature pertaining to its use in the study of the uteroplacental circulation. The second part of the thesis is devoted to the effect of nifedipine on fetal umbilical artery Doppler waveform analysis. In the first ·stage of the investigation the effect of the drug on hypertensive mothers has been examined, and in the second stage the effect on fetuses that have an increased resistance index of the umbilical artery Doppler waveform. 2018-01-30T13:59:51Z 2018-01-30T13:59:51Z 1992 Master Thesis Masters MMed http://hdl.handle.net/11427/27134 eng application/pdf Department of Obstetrics and Gynaecology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Obstetrics and Gynaecology Ultrasonic imaging Nifedipine - pharmacology Umbilical Arteries - drug effects Ultrasonography, Prenatal Puzey, Martin Stanley The investigation of the calcium antagonist nifedipine on fetal umbilical artery Doppler waveforms |
| thesis_degree_str | Master's |
| title | The investigation of the calcium antagonist nifedipine on fetal umbilical artery Doppler waveforms |
| title_full | The investigation of the calcium antagonist nifedipine on fetal umbilical artery Doppler waveforms |
| title_fullStr | The investigation of the calcium antagonist nifedipine on fetal umbilical artery Doppler waveforms |
| title_full_unstemmed | The investigation of the calcium antagonist nifedipine on fetal umbilical artery Doppler waveforms |
| title_short | The investigation of the calcium antagonist nifedipine on fetal umbilical artery Doppler waveforms |
| title_sort | investigation of the calcium antagonist nifedipine on fetal umbilical artery doppler waveforms |
| topic | Obstetrics and Gynaecology Ultrasonic imaging Nifedipine - pharmacology Umbilical Arteries - drug effects Ultrasonography, Prenatal |
| url | http://hdl.handle.net/11427/27134 |
| work_keys_str_mv | AT puzeymartinstanley theinvestigationofthecalciumantagonistnifedipineonfetalumbilicalarterydopplerwaveforms AT puzeymartinstanley investigationofthecalciumantagonistnifedipineonfetalumbilicalarterydopplerwaveforms |