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GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells
Gonadotropin-releasing hormone (GnRH) and its superactive analogues are currently being used in the treatment of a number of endocrine disorders, such as endometriosis, precocious puberty, infertility and prostatic cancer. Selection of these analogues for clinical use have been previously based on t...
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| Format: | Thesis |
| Language: | English |
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Division of Chemical Pathology
2018
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| _version_ | 1867613169453629440 |
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| access_status_str | Open Access |
| author | Wormald, Patricia J |
| author2 | Millar, Robert P |
| author_browse | Millar, Robert P Wormald, Patricia J |
| author_facet | Millar, Robert P Wormald, Patricia J |
| author_sort | Wormald, Patricia J |
| collection | Thesis |
| description | Gonadotropin-releasing hormone (GnRH) and its superactive analogues are currently being used in the treatment of a number of endocrine disorders, such as endometriosis, precocious puberty, infertility and prostatic cancer. Selection of these analogues for clinical use have been previously based on their activities in animal models. This thesis has therefore investigated the binding characteristics of the human GnRH receptor, in comparison to those of the rat receptor, as well as the activities of a number of GnRH analogues for stimulating luteinising hormone (LH) and follicle stimulating hormone (FSH) secretion from cultured human pituitary cells. The establishment of a human pituitary bioassay system has further made possible the investigation of the direct regulatory roles of GnRH and other neuropeptides in man. To date, such studies in man have been performed in vivo and are thus complicated by the simultaneous interactions of numerous modulators. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/27168 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:52.071Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Division of Chemical Pathology |
| publisherStr | Division of Chemical Pathology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/27168 GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells Wormald, Patricia J Millar, Robert P Gonadotropin Pituitary hormones Pituitary body Hormone receptors Gonadotrophins, Pituitary - Secretion Neuropeptides Pituitary Gland Pituitary Hormone-Releasing Hormones Receptors, Gonadoliberin Subs Gonadotropin-releasing hormone (GnRH) and its superactive analogues are currently being used in the treatment of a number of endocrine disorders, such as endometriosis, precocious puberty, infertility and prostatic cancer. Selection of these analogues for clinical use have been previously based on their activities in animal models. This thesis has therefore investigated the binding characteristics of the human GnRH receptor, in comparison to those of the rat receptor, as well as the activities of a number of GnRH analogues for stimulating luteinising hormone (LH) and follicle stimulating hormone (FSH) secretion from cultured human pituitary cells. The establishment of a human pituitary bioassay system has further made possible the investigation of the direct regulatory roles of GnRH and other neuropeptides in man. To date, such studies in man have been performed in vivo and are thus complicated by the simultaneous interactions of numerous modulators. 2018-01-31T13:44:44Z 2018-01-31T13:44:44Z 1988 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/27168 eng application/pdf Division of Chemical Pathology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Gonadotropin Pituitary hormones Pituitary body Hormone receptors Gonadotrophins, Pituitary - Secretion Neuropeptides Pituitary Gland Pituitary Hormone-Releasing Hormones Receptors, Gonadoliberin Subs Wormald, Patricia J GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells |
| thesis_degree_str | Doctoral |
| title | GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells |
| title_full | GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells |
| title_fullStr | GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells |
| title_full_unstemmed | GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells |
| title_short | GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells |
| title_sort | gnrh and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells |
| topic | Gonadotropin Pituitary hormones Pituitary body Hormone receptors Gonadotrophins, Pituitary - Secretion Neuropeptides Pituitary Gland Pituitary Hormone-Releasing Hormones Receptors, Gonadoliberin Subs |
| url | http://hdl.handle.net/11427/27168 |
| work_keys_str_mv | AT wormaldpatriciaj gnrhandneuropeptideregulationofgonadotropinsecretionfromculturedhumanpituitarycells |