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The iron-binding proteins of iron-absorbing rat intestinal mucosa
Iron deficiency anaemia is perhaps the most widespread nutritional deficiency disease; as result, the topic of iron absorption has received intensive investigation over a relatively long period of time. Most of the investigative thrust has come from clinical medicine and allied fields, with some ass...
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| Format: | Thesis |
| Language: | English |
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Division of Clinical Haematology
2018
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| _version_ | 1867613956904845312 |
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| access_status_str | Open Access |
| author | Johnson, Glynis |
| author2 | Purvis, Langley R |
| author_browse | Johnson, Glynis Purvis, Langley R |
| author_facet | Purvis, Langley R Johnson, Glynis |
| author_sort | Johnson, Glynis |
| collection | Thesis |
| description | Iron deficiency anaemia is perhaps the most widespread nutritional deficiency disease; as result, the topic of iron absorption has received intensive investigation over a relatively long period of time. Most of the investigative thrust has come from clinical medicine and allied fields, with some associated biochemical investigation. Evidence from the latter has pointed towards the involvement of iron-binding proteins especially ferritin and transferrin in the absorptive process. While the biochemical literature on these two proteins, particularly transferrin, is vast, their roles in iron absorption are obscure. This study was undertaken, therefore, as an investigation into these proteins, their quantitation and role in iron absorption. The physiology of absorption was studied by injection of radiolabelled ferrous ascorbate into isolated intestinal loops and the determination of mucosal, blood and carcass uptake. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/27263 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:44:23.662Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Division of Clinical Haematology |
| publisherStr | Division of Clinical Haematology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/27263 The iron-binding proteins of iron-absorbing rat intestinal mucosa Johnson, Glynis Purvis, Langley R Jacobs, Peter iron-binding proteins Iron deficiency anaemia is perhaps the most widespread nutritional deficiency disease; as result, the topic of iron absorption has received intensive investigation over a relatively long period of time. Most of the investigative thrust has come from clinical medicine and allied fields, with some associated biochemical investigation. Evidence from the latter has pointed towards the involvement of iron-binding proteins especially ferritin and transferrin in the absorptive process. While the biochemical literature on these two proteins, particularly transferrin, is vast, their roles in iron absorption are obscure. This study was undertaken, therefore, as an investigation into these proteins, their quantitation and role in iron absorption. The physiology of absorption was studied by injection of radiolabelled ferrous ascorbate into isolated intestinal loops and the determination of mucosal, blood and carcass uptake. 2018-02-05T12:36:42Z 2018-02-05T12:36:42Z 1983 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/27263 eng application/pdf Division of Clinical Haematology Faculty of Health Sciences University of Cape Town |
| spellingShingle | iron-binding proteins Johnson, Glynis The iron-binding proteins of iron-absorbing rat intestinal mucosa |
| thesis_degree_str | Doctoral |
| title | The iron-binding proteins of iron-absorbing rat intestinal mucosa |
| title_full | The iron-binding proteins of iron-absorbing rat intestinal mucosa |
| title_fullStr | The iron-binding proteins of iron-absorbing rat intestinal mucosa |
| title_full_unstemmed | The iron-binding proteins of iron-absorbing rat intestinal mucosa |
| title_short | The iron-binding proteins of iron-absorbing rat intestinal mucosa |
| title_sort | iron binding proteins of iron absorbing rat intestinal mucosa |
| topic | iron-binding proteins |
| url | http://hdl.handle.net/11427/27263 |
| work_keys_str_mv | AT johnsonglynis theironbindingproteinsofironabsorbingratintestinalmucosa AT johnsonglynis ironbindingproteinsofironabsorbingratintestinalmucosa |