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A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP)

Includes bibliographical references (leaves 96-114).

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Main Author: Paulsen, Janis
Other Authors: Douglass, Nicola
Format: Thesis
Language:English
Published: Division of Virology 2014
Subjects:
Medical Virology
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access_status_str Open Access
author Paulsen, Janis
author2 Douglass, Nicola
author_browse Douglass, Nicola
Paulsen, Janis
author_facet Douglass, Nicola
Paulsen, Janis
author_sort Paulsen, Janis
collection Thesis
description Includes bibliographical references (leaves 96-114).
format Thesis
id oai:open.uct.ac.za:11427/2733
institution University of Cape Town (South Africa)
language eng
last_indexed 2026-06-10T12:34:06.076Z
license_str Not specified — see source repository
provenance_str_mv Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository
publishDate 2014
publishDateRange 2014
publishDateSort 2014
publisher Division of Virology
publisherStr Division of Virology
record_format dspace
source_str UCTD — University of Cape Town Open Access Repository
spelling oai:open.uct.ac.za:11427/2733 A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP) Paulsen, Janis Douglass, Nicola Williamson, Anna-Lise Medical Virology Includes bibliographical references (leaves 96-114). Cowpox virus has been found to encode the inflammation modulatory protein (IMP) (Miller, C.G., 1997), a homologue vaccinia virus complement control protein (VCP). VCP belongs to regulation of complement activation (RCA) protein superfamily. It has been shown to inhibit both the alternative and classical pathways of complement activation by binding to the proteins C3 and C4, thereby preventing complementmediated opsonisation of virus, antibody-mediated lysis of infected cells and migration of inflammatory cells into the site of infection. VCP also possesses heparin binding sites. 2014-07-28T08:21:48Z 2014-07-28T08:21:48Z 2007 Master Thesis Masters MSc http://hdl.handle.net/11427/2733 eng application/pdf Division of Virology Faculty of Health Sciences University of Cape Town
spellingShingle Medical Virology
Paulsen, Janis
A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP)
thesis_degree_str Master's
title A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP)
title_full A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP)
title_fullStr A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP)
title_full_unstemmed A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP)
title_short A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP)
title_sort comparative analysis of cowpox virus cpv wt and a deletion mutant lacking the gene encoding the inflammation modulatory protein cpv imp
topic Medical Virology
url http://hdl.handle.net/11427/2733
work_keys_str_mv AT paulsenjanis acomparativeanalysisofcowpoxviruscpvwtandadeletionmutantlackingthegeneencodingtheinflammationmodulatoryproteincpvimp
AT paulsenjanis comparativeanalysisofcowpoxviruscpvwtandadeletionmutantlackingthegeneencodingtheinflammationmodulatoryproteincpvimp

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