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Ependymal tumours in childhood: outcomes and prognostic factors

OBJECTIVES: To retrospectively review the patient demographics, disease profile and treatment outcomes of paediatric patients treated for ependymoma at our institution. STUDY DESIGN AND METHODS: 51 eligible patients were treated between 1980 and 2013. The median age at presentation was 6 years. The...

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Main Author: Nkosi, Zanele
Other Authors: Parkes, Jeannette
Format: Thesis
Language:English
Published: Division of Radiation Oncology 2018
Subjects:
Radiation Oncology
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access_status_str Open Access
author Nkosi, Zanele
author2 Parkes, Jeannette
author_browse Nkosi, Zanele
Parkes, Jeannette
author_facet Parkes, Jeannette
Nkosi, Zanele
author_sort Nkosi, Zanele
collection Thesis
description OBJECTIVES: To retrospectively review the patient demographics, disease profile and treatment outcomes of paediatric patients treated for ependymoma at our institution. STUDY DESIGN AND METHODS: 51 eligible patients were treated between 1980 and 2013. The median age at presentation was 6 years. The majority of patients were male (66,7%), had infratentorial tumours (62,7%) and had low-grade tumours (70,6%). Gross total resection (GTR) was achieved in 22 patients (43,1%). Thirtyeight patients received adjuvant radiotherapy (76,5%) and 10 (19,6%) received adjuvant chemotherapy. RESULTS: The 5-year overall survival (OS) was 63,3 % (median follow up of 46 months). The 5 year progression free survival (PFS) was 50,70%. Seventeen (33,3%) patients experienced treatment failure, of which 13 (76,5%) represented local failure. The median time to first relapse was 20 months. The 5 year PFS for children > 3 was 50,0 % and 27,7% for children ≤ 3 years of age (p = 0.0356). GTR had a superior 5- year OS of 73,9% over subtotal resection with a value of 56,7% (p = 0.0016). Similarly an improved 5-year PFS of 70,3% versus 29,1% was observed with GTR over subtotal resection (p = <0.0001). Patients who received adjuvant radiotherapy (RT) had significantly better outcomes than those in whom RT was not given (p = <0.0001, 5 year OS of 69,7% versus 37,5%). CONCLUSION: This review confirms the finding that GTR is associated with improved outcomes and that adjuvant radiation therapy positively impacts survival. The worse outcomes in the younger age group requires further evaluation and possible change in treatment protocol for this group of patients.
format Thesis
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institution University of Cape Town (South Africa)
language eng
last_indexed 2026-06-10T12:31:52.071Z
license_str Not specified — see source repository
provenance_str_mv Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository
publishDate 2018
publishDateRange 2018
publishDateSort 2018
publisher Division of Radiation Oncology
publisherStr Division of Radiation Oncology
record_format dspace
source_str UCTD — University of Cape Town Open Access Repository
spelling oai:open.uct.ac.za:11427/27398 Ependymal tumours in childhood: outcomes and prognostic factors Nkosi, Zanele Parkes, Jeannette Hunter, Alistair Radiation Oncology OBJECTIVES: To retrospectively review the patient demographics, disease profile and treatment outcomes of paediatric patients treated for ependymoma at our institution. STUDY DESIGN AND METHODS: 51 eligible patients were treated between 1980 and 2013. The median age at presentation was 6 years. The majority of patients were male (66,7%), had infratentorial tumours (62,7%) and had low-grade tumours (70,6%). Gross total resection (GTR) was achieved in 22 patients (43,1%). Thirtyeight patients received adjuvant radiotherapy (76,5%) and 10 (19,6%) received adjuvant chemotherapy. RESULTS: The 5-year overall survival (OS) was 63,3 % (median follow up of 46 months). The 5 year progression free survival (PFS) was 50,70%. Seventeen (33,3%) patients experienced treatment failure, of which 13 (76,5%) represented local failure. The median time to first relapse was 20 months. The 5 year PFS for children > 3 was 50,0 % and 27,7% for children ≤ 3 years of age (p = 0.0356). GTR had a superior 5- year OS of 73,9% over subtotal resection with a value of 56,7% (p = 0.0016). Similarly an improved 5-year PFS of 70,3% versus 29,1% was observed with GTR over subtotal resection (p = <0.0001). Patients who received adjuvant radiotherapy (RT) had significantly better outcomes than those in whom RT was not given (p = <0.0001, 5 year OS of 69,7% versus 37,5%). CONCLUSION: This review confirms the finding that GTR is associated with improved outcomes and that adjuvant radiation therapy positively impacts survival. The worse outcomes in the younger age group requires further evaluation and possible change in treatment protocol for this group of patients. 2018-02-07T12:10:30Z 2018-02-07T12:10:30Z 2017 Master Thesis Masters MMed http://hdl.handle.net/11427/27398 eng application/pdf Division of Radiation Oncology Faculty of Health Sciences University of Cape Town
spellingShingle Radiation Oncology
Nkosi, Zanele
Ependymal tumours in childhood: outcomes and prognostic factors
thesis_degree_str Master's
title Ependymal tumours in childhood: outcomes and prognostic factors
title_full Ependymal tumours in childhood: outcomes and prognostic factors
title_fullStr Ependymal tumours in childhood: outcomes and prognostic factors
title_full_unstemmed Ependymal tumours in childhood: outcomes and prognostic factors
title_short Ependymal tumours in childhood: outcomes and prognostic factors
title_sort ependymal tumours in childhood outcomes and prognostic factors
topic Radiation Oncology
url http://hdl.handle.net/11427/27398
work_keys_str_mv AT nkosizanele ependymaltumoursinchildhoodoutcomesandprognosticfactors

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