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Radiological differences between HIV-positive and HIV-negative children with cholesteatoma
Introduction: HIV-positive children are possibly more prone to developing cholesteatoma. Chronic inflammation of the middle ear cleft may be more common in patients with HIV and this may predispose HIV-positive children to developing cholesteatoma. There are no studies that describe the radiological...
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| Format: | Thesis |
| Language: | English |
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Division of Otorhinolaryngology
2018
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| _version_ | 1867614520443142144 |
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| access_status_str | Open Access |
| author | Mc Guire, Jessica Kate |
| author2 | Harris, Tashneem |
| author_browse | Harris, Tashneem Mc Guire, Jessica Kate |
| author_facet | Harris, Tashneem Mc Guire, Jessica Kate |
| author_sort | Mc Guire, Jessica Kate |
| collection | Thesis |
| description | Introduction: HIV-positive children are possibly more prone to developing cholesteatoma. Chronic inflammation of the middle ear cleft may be more common in patients with HIV and this may predispose HIV-positive children to developing cholesteatoma. There are no studies that describe the radiological morphology of the middle ear cleft in HIV-positive compared to HIV-negative children with cholesteatoma. Aim: Compare the radiological differences of the middle ear cleft in HIV-positive and HIV-negative children with cholesteatoma. Method A retrospective, cross-sectional, observational analytical review of patients with cholesteatoma at Red Cross War Memorial Children's Hospital over a 6 year period. Results: Forty patients were included in the study, 11 of whom had bilateral cholesteatoma and therefore 51 ears were eligible for our evaluation. HIV-positive patients had smaller (p=0.02) mastoid air cell systems (MACS). Forty percent of HIV-positive patients had sclerotic mastoids, whereas the rate was 3% in HIV-negative ears (p<0.02). Eighty-two percent of the HIV-positive patients had bilateral cholesteatoma compared to 7% of the control group (p<0.02). There was no difference between the 2 groups with regards to aeration of the middle ear cleft, bony erosion of middle ear structures, Eustachian tube obstruction or soft tissue occlusion of the post-nasal space. Conclusion: HIV-positive paediatric patients with cholesteatoma are more likely to have smaller, sclerotic mastoids compared to HIV-negative patients. They are significantly more likely to have bilateral cholesteatoma. This may have implications in terms of surveillance of HIV-positive children, as well as, an approach to management, recurrence and follow-up. HIV infection should be flagged as a risk factor for developing cholesteatoma. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/27435 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:53:21.094Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Division of Otorhinolaryngology |
| publisherStr | Division of Otorhinolaryngology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/27435 Radiological differences between HIV-positive and HIV-negative children with cholesteatoma Mc Guire, Jessica Kate Harris, Tashneem Fagan, Johannes J Otorhinolaryngology Introduction: HIV-positive children are possibly more prone to developing cholesteatoma. Chronic inflammation of the middle ear cleft may be more common in patients with HIV and this may predispose HIV-positive children to developing cholesteatoma. There are no studies that describe the radiological morphology of the middle ear cleft in HIV-positive compared to HIV-negative children with cholesteatoma. Aim: Compare the radiological differences of the middle ear cleft in HIV-positive and HIV-negative children with cholesteatoma. Method A retrospective, cross-sectional, observational analytical review of patients with cholesteatoma at Red Cross War Memorial Children's Hospital over a 6 year period. Results: Forty patients were included in the study, 11 of whom had bilateral cholesteatoma and therefore 51 ears were eligible for our evaluation. HIV-positive patients had smaller (p=0.02) mastoid air cell systems (MACS). Forty percent of HIV-positive patients had sclerotic mastoids, whereas the rate was 3% in HIV-negative ears (p<0.02). Eighty-two percent of the HIV-positive patients had bilateral cholesteatoma compared to 7% of the control group (p<0.02). There was no difference between the 2 groups with regards to aeration of the middle ear cleft, bony erosion of middle ear structures, Eustachian tube obstruction or soft tissue occlusion of the post-nasal space. Conclusion: HIV-positive paediatric patients with cholesteatoma are more likely to have smaller, sclerotic mastoids compared to HIV-negative patients. They are significantly more likely to have bilateral cholesteatoma. This may have implications in terms of surveillance of HIV-positive children, as well as, an approach to management, recurrence and follow-up. HIV infection should be flagged as a risk factor for developing cholesteatoma. 2018-02-09T07:26:04Z 2018-02-09T07:26:04Z 2017 Master Thesis Masters MMed http://hdl.handle.net/11427/27435 eng application/pdf Division of Otorhinolaryngology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Otorhinolaryngology Mc Guire, Jessica Kate Radiological differences between HIV-positive and HIV-negative children with cholesteatoma |
| thesis_degree_str | Master's |
| title | Radiological differences between HIV-positive and HIV-negative children with cholesteatoma |
| title_full | Radiological differences between HIV-positive and HIV-negative children with cholesteatoma |
| title_fullStr | Radiological differences between HIV-positive and HIV-negative children with cholesteatoma |
| title_full_unstemmed | Radiological differences between HIV-positive and HIV-negative children with cholesteatoma |
| title_short | Radiological differences between HIV-positive and HIV-negative children with cholesteatoma |
| title_sort | radiological differences between hiv positive and hiv negative children with cholesteatoma |
| topic | Otorhinolaryngology |
| url | http://hdl.handle.net/11427/27435 |
| work_keys_str_mv | AT mcguirejessicakate radiologicaldifferencesbetweenhivpositiveandhivnegativechildrenwithcholesteatoma |