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The first-pass extraction of pindolol in comparison with propranolol in rat liver
Reports in the literature have shown that in man propranolol has a larger first-pass effect (70%) than pindolol (13%). The aim of this research was to make a direct comparison of first-pass extraction and other pharmacokinetic parameters of these drugs under identical experimental conditions by mean...
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Division of Clinical Pharmacology
2018
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| _version_ | 1867613250790621184 |
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| access_status_str | Open Access |
| author | Basset, Helen Margaret |
| author2 | Folb, Peter I |
| author_browse | Basset, Helen Margaret Folb, Peter I |
| author_facet | Folb, Peter I Basset, Helen Margaret |
| author_sort | Basset, Helen Margaret |
| collection | Thesis |
| description | Reports in the literature have shown that in man propranolol has a larger first-pass effect (70%) than pindolol (13%). The aim of this research was to make a direct comparison of first-pass extraction and other pharmacokinetic parameters of these drugs under identical experimental conditions by means of an isolated rat liver perfusion model. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/27659 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:10.259Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Division of Clinical Pharmacology |
| publisherStr | Division of Clinical Pharmacology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/27659 The first-pass extraction of pindolol in comparison with propranolol in rat liver Basset, Helen Margaret Folb, Peter I Pindolol Propanolol Perfusion Reports in the literature have shown that in man propranolol has a larger first-pass effect (70%) than pindolol (13%). The aim of this research was to make a direct comparison of first-pass extraction and other pharmacokinetic parameters of these drugs under identical experimental conditions by means of an isolated rat liver perfusion model. 2018-03-15T07:38:53Z 2018-03-15T07:38:53Z 1979 Master Thesis Masters MSc (Med) http://hdl.handle.net/11427/27659 eng application/pdf Division of Clinical Pharmacology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Pindolol Propanolol Perfusion Basset, Helen Margaret The first-pass extraction of pindolol in comparison with propranolol in rat liver |
| thesis_degree_str | Master's |
| title | The first-pass extraction of pindolol in comparison with propranolol in rat liver |
| title_full | The first-pass extraction of pindolol in comparison with propranolol in rat liver |
| title_fullStr | The first-pass extraction of pindolol in comparison with propranolol in rat liver |
| title_full_unstemmed | The first-pass extraction of pindolol in comparison with propranolol in rat liver |
| title_short | The first-pass extraction of pindolol in comparison with propranolol in rat liver |
| title_sort | first pass extraction of pindolol in comparison with propranolol in rat liver |
| topic | Pindolol Propanolol Perfusion |
| url | http://hdl.handle.net/11427/27659 |
| work_keys_str_mv | AT bassethelenmargaret thefirstpassextractionofpindololincomparisonwithpropranololinratliver AT bassethelenmargaret firstpassextractionofpindololincomparisonwithpropranololinratliver |