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Exercise-induced protection against insulin resistance and type 11 diabetes : the role of calcium
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
MRC/UCT RU for Exercise and Sport Medicine
2014
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| _version_ | 1867614446951596032 |
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| access_status_str | Open Access |
| author | Smith, James Antony Harris |
| author2 | Ojuka, Edward |
| author_browse | Ojuka, Edward Smith, James Antony Harris |
| author_facet | Ojuka, Edward Smith, James Antony Harris |
| author_sort | Smith, James Antony Harris |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/2767 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:52:11.007Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | MRC/UCT RU for Exercise and Sport Medicine |
| publisherStr | MRC/UCT RU for Exercise and Sport Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/2767 Exercise-induced protection against insulin resistance and type 11 diabetes : the role of calcium Smith, James Antony Harris Ojuka, Edward Collins, Malcolm Exercise Science Includes abstract. Includes bibliographical references (p. 89-106). Regular exercise protects individuals against developing insulin resistance and type II diabetes. This effect of exercise does not appear to be due to an improvement in the insulin signalling pathway but instead due to an increase in the content of the insulin-regulatable glucose transporter (GLUT4) in skeletal muscle (84). Understanding the mechanisms by which exercise increases GLUT4 levels in skeletal muscle may reveal targets for pharmaceuticals to treat insulin resistance and type II diabetes. Although in vitro binding assays have shown that GLUT4 expression during exercise is mediated by the binding of myocyte enhancer factor-2A (MEF2A) to its cis-element on the Glut4 promoter (122), this has not been demonstrated in vivo. Moreover, the mechanisms by which exercise increases MEF2A binding to the Glut4 promoter have not been fully characterised. 2014-07-28T08:23:53Z 2014-07-28T08:23:53Z 2008 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/2767 eng application/pdf MRC/UCT RU for Exercise and Sport Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Exercise Science Smith, James Antony Harris Exercise-induced protection against insulin resistance and type 11 diabetes : the role of calcium |
| thesis_degree_str | Doctoral |
| title | Exercise-induced protection against insulin resistance and type 11 diabetes : the role of calcium |
| title_full | Exercise-induced protection against insulin resistance and type 11 diabetes : the role of calcium |
| title_fullStr | Exercise-induced protection against insulin resistance and type 11 diabetes : the role of calcium |
| title_full_unstemmed | Exercise-induced protection against insulin resistance and type 11 diabetes : the role of calcium |
| title_short | Exercise-induced protection against insulin resistance and type 11 diabetes : the role of calcium |
| title_sort | exercise induced protection against insulin resistance and type 11 diabetes the role of calcium |
| topic | Exercise Science |
| url | http://hdl.handle.net/11427/2767 |
| work_keys_str_mv | AT smithjamesantonyharris exerciseinducedprotectionagainstinsulinresistanceandtype11diabetestheroleofcalcium |