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Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart
Bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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MRC/UCT Cape Heart Centre
2014
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| _version_ | 1867613295869952000 |
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| access_status_str | Open Access |
| author | Makaula, Siyanda S S |
| author2 | Opie, Lionel H |
| author_browse | Makaula, Siyanda S S Opie, Lionel H |
| author_facet | Opie, Lionel H Makaula, Siyanda S S |
| author_sort | Makaula, Siyanda S S |
| collection | Thesis |
| description | Bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/2789 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:51.607Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | MRC/UCT Cape Heart Centre |
| publisherStr | MRC/UCT Cape Heart Centre |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/2789 Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart Makaula, Siyanda S S Opie, Lionel H Sack, Michael N Bibliographical references. Cardiac ischaemic preconditioning (IPC) describes a biological phenomenon whereby a short ischaemic stimulus confers protection to the heart against subsequent prolonged ischaemia and reperfusion injury. Understanding this survival programme will enable us to augment tissue tolerance against cell death. Ischaemic preconditioning is poorly understood, however, certain metabolic events and activation intracellular signalling events are known to trigger this cardioprotection. The purpose of this study was to investigate the metabolic and intracellular signalling events which occur during ischaemic preconditioning and their effects on improvement of contractile recovery following an ischaemia/reperfusion insult. 2014-07-28T11:02:07Z 2014-07-28T11:02:07Z 2000 Master Thesis Masters MSc http://hdl.handle.net/11427/2789 eng application/pdf MRC/UCT Cape Heart Centre Faculty of Health Sciences University of Cape Town |
| spellingShingle | Makaula, Siyanda S S Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart |
| thesis_degree_str | Master's |
| title | Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart |
| title_full | Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart |
| title_fullStr | Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart |
| title_full_unstemmed | Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart |
| title_short | Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart |
| title_sort | preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart |
| url | http://hdl.handle.net/11427/2789 |
| work_keys_str_mv | AT makaulasiyandass preconditioningandaugmentedpreconditioningviamanipulationofmetabolicandsignallingpathwaysintheratheart |