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A retrospective observational study of the effectiveness of long acting antipsychotic injectable on hospital admissions
Background: The impact on hospitalisations/ relapse rates of utilising long-acting antipsychotic injectable (LAIs) in a South African population suffering from chronic psychotic spectrum mental illness is poorly researched. Aim: To compare the duration and number of hospitalisation episodes 12 and 2...
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| Format: | Thesis |
| Language: | English |
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Department of Psychiatry and Mental Health
2019
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| _version_ | 1867613339449819136 |
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| access_status_str | Open Access |
| author | Charles, Bhaskaran Nathamaniar |
| author2 | Horn, Neil |
| author_browse | Charles, Bhaskaran Nathamaniar Horn, Neil |
| author_facet | Horn, Neil Charles, Bhaskaran Nathamaniar |
| author_sort | Charles, Bhaskaran Nathamaniar |
| collection | Thesis |
| description | Background: The impact on hospitalisations/ relapse rates of utilising long-acting antipsychotic injectable (LAIs) in a South African population suffering from chronic psychotic spectrum mental illness is poorly researched. Aim: To compare the duration and number of hospitalisation episodes 12 and 24 months before and after the initiation of a LAI. Setting: Valkenberg Hospital’s adult acute inpatient psychiatry services. Method: This was a retrospective naturalistic observational mirror-image study. Hospitalisation was utilised as a proxy for relapse. Results: Sixty-one patients were identified for the study. A comparison of the 12 months before LAI initiation to the 12 months following LAI initiation showed a reduction in the number of admissions of 44% (55 to 31), and a reduction in the number of inpatient days of 23% (1892 to 1464). There was a statistically significant reduction in the median number of hospital admissions (p = 0.005) and median inpatient days (p = 0.040). Comparing the 24 months before to the 24 months following LAI initiation, there was a reduction in the number of admissions of 30% (91 to 64) and inpatient days of 4% (3477 to 3355). There was a statistically significant reduction in the median number of hospital admissions (p = 0.014) and a non-statistically significant reduction in median days (p = 0.428). Conclusion: The prescription of a LAI reduced the duration and number of hospital admissions over a 12-month period. After 24 months, there were fewer admissions but no significant reduction in the number of inpatient days. This study supports findings of international mirror-image studies. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/29562 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:33.896Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Department of Psychiatry and Mental Health |
| publisherStr | Department of Psychiatry and Mental Health |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/29562 A retrospective observational study of the effectiveness of long acting antipsychotic injectable on hospital admissions Charles, Bhaskaran Nathamaniar Horn, Neil Williams-Ashman, Peter Psychiatry Background: The impact on hospitalisations/ relapse rates of utilising long-acting antipsychotic injectable (LAIs) in a South African population suffering from chronic psychotic spectrum mental illness is poorly researched. Aim: To compare the duration and number of hospitalisation episodes 12 and 24 months before and after the initiation of a LAI. Setting: Valkenberg Hospital’s adult acute inpatient psychiatry services. Method: This was a retrospective naturalistic observational mirror-image study. Hospitalisation was utilised as a proxy for relapse. Results: Sixty-one patients were identified for the study. A comparison of the 12 months before LAI initiation to the 12 months following LAI initiation showed a reduction in the number of admissions of 44% (55 to 31), and a reduction in the number of inpatient days of 23% (1892 to 1464). There was a statistically significant reduction in the median number of hospital admissions (p = 0.005) and median inpatient days (p = 0.040). Comparing the 24 months before to the 24 months following LAI initiation, there was a reduction in the number of admissions of 30% (91 to 64) and inpatient days of 4% (3477 to 3355). There was a statistically significant reduction in the median number of hospital admissions (p = 0.014) and a non-statistically significant reduction in median days (p = 0.428). Conclusion: The prescription of a LAI reduced the duration and number of hospital admissions over a 12-month period. After 24 months, there were fewer admissions but no significant reduction in the number of inpatient days. This study supports findings of international mirror-image studies. 2019-02-18T09:16:07Z 2019-02-18T09:16:07Z 2018 2019-02-18T09:00:31Z Master Thesis Masters MMed http://hdl.handle.net/11427/29562 eng application/pdf Department of Psychiatry and Mental Health Faculty of Health Sciences University of Cape Town |
| spellingShingle | Psychiatry Charles, Bhaskaran Nathamaniar A retrospective observational study of the effectiveness of long acting antipsychotic injectable on hospital admissions |
| thesis_degree_str | Master's |
| title | A retrospective observational study of the effectiveness of long acting antipsychotic injectable on hospital admissions |
| title_full | A retrospective observational study of the effectiveness of long acting antipsychotic injectable on hospital admissions |
| title_fullStr | A retrospective observational study of the effectiveness of long acting antipsychotic injectable on hospital admissions |
| title_full_unstemmed | A retrospective observational study of the effectiveness of long acting antipsychotic injectable on hospital admissions |
| title_short | A retrospective observational study of the effectiveness of long acting antipsychotic injectable on hospital admissions |
| title_sort | retrospective observational study of the effectiveness of long acting antipsychotic injectable on hospital admissions |
| topic | Psychiatry |
| url | http://hdl.handle.net/11427/29562 |
| work_keys_str_mv | AT charlesbhaskarannathamaniar aretrospectiveobservationalstudyoftheeffectivenessoflongactingantipsychoticinjectableonhospitaladmissions AT charlesbhaskarannathamaniar retrospectiveobservationalstudyoftheeffectivenessoflongactingantipsychoticinjectableonhospitaladmissions |