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Maternal and fetal outcome of subsequent pregnancy in patients with documented peripartum cardiomyopathy
AIM: Subsequent pregnancies (SSPs) in patients with peripartum cardiomyopathy (PPCM) have a high risk of heart failure relapse. We report on outcome of SSPs in PPCM patients in South Africa. METHODS AND RESULTS: Of the 18 PPCM patients with a SSP, 3 patients died within 6-months follow-up. Overall r...
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| Format: | Thesis |
| Language: | English |
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Division of Cardiology
2019
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| _version_ | 1867614434972663808 |
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| access_status_str | Open Access |
| author | Masuku, David Sifiso |
| author2 | Sliwa, Karen |
| author_browse | Masuku, David Sifiso Sliwa, Karen |
| author_facet | Sliwa, Karen Masuku, David Sifiso |
| author_sort | Masuku, David Sifiso |
| collection | Thesis |
| description | AIM: Subsequent pregnancies (SSPs) in patients with peripartum cardiomyopathy (PPCM) have a high risk of heart failure relapse. We report on outcome of SSPs in PPCM patients in South Africa. METHODS AND RESULTS: Of the 18 PPCM patients with a SSP, 3 patients died within 6-months follow-up. Overall relapse rate, left ventricular ejection fraction (LVEF) <50% or death after at least 6 months follow-up, was 30%, with 16% (3/18) mortality. Persistently reduced LVEF (<50%) before entering SSP was present in 44% of patients, while full recovery (LVEF≥ 50%) was present in 85%. Persistently reduced LVEF before SSP was associated with a higher mortality (27% vs 0%) and a lower rate of full recovery at follow-up. Patients obtaining standard therapy for heart failure and bromocriptine immediately after delivery displayed significantly better LVEF at follow-up and a higher rate of full recovery, with no patient dying, compared with patients obtaining standard therapy for heart failure alone. CONCLUSION: Full recovery of LVEF before SSP was associated with lower mortality and better cardiac function at follow-up. Addition of bromocriptine to standard therapy for heart failure immediately after delivery was safe and appeared to be associated with better outcome of SSP in our patients. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/29669 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:51:59.583Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Division of Cardiology |
| publisherStr | Division of Cardiology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/29669 Maternal and fetal outcome of subsequent pregnancy in patients with documented peripartum cardiomyopathy Masuku, David Sifiso Sliwa, Karen Peripartum Cardiomyopathy AIM: Subsequent pregnancies (SSPs) in patients with peripartum cardiomyopathy (PPCM) have a high risk of heart failure relapse. We report on outcome of SSPs in PPCM patients in South Africa. METHODS AND RESULTS: Of the 18 PPCM patients with a SSP, 3 patients died within 6-months follow-up. Overall relapse rate, left ventricular ejection fraction (LVEF) <50% or death after at least 6 months follow-up, was 30%, with 16% (3/18) mortality. Persistently reduced LVEF (<50%) before entering SSP was present in 44% of patients, while full recovery (LVEF≥ 50%) was present in 85%. Persistently reduced LVEF before SSP was associated with a higher mortality (27% vs 0%) and a lower rate of full recovery at follow-up. Patients obtaining standard therapy for heart failure and bromocriptine immediately after delivery displayed significantly better LVEF at follow-up and a higher rate of full recovery, with no patient dying, compared with patients obtaining standard therapy for heart failure alone. CONCLUSION: Full recovery of LVEF before SSP was associated with lower mortality and better cardiac function at follow-up. Addition of bromocriptine to standard therapy for heart failure immediately after delivery was safe and appeared to be associated with better outcome of SSP in our patients. 2019-02-19T13:08:02Z 2019-02-19T13:08:02Z 2018 2019-02-19T11:14:51Z Master Thesis Masters MMed http://hdl.handle.net/11427/29669 eng application/pdf Division of Cardiology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Peripartum Cardiomyopathy Masuku, David Sifiso Maternal and fetal outcome of subsequent pregnancy in patients with documented peripartum cardiomyopathy |
| thesis_degree_str | Master's |
| title | Maternal and fetal outcome of subsequent pregnancy in patients with documented peripartum cardiomyopathy |
| title_full | Maternal and fetal outcome of subsequent pregnancy in patients with documented peripartum cardiomyopathy |
| title_fullStr | Maternal and fetal outcome of subsequent pregnancy in patients with documented peripartum cardiomyopathy |
| title_full_unstemmed | Maternal and fetal outcome of subsequent pregnancy in patients with documented peripartum cardiomyopathy |
| title_short | Maternal and fetal outcome of subsequent pregnancy in patients with documented peripartum cardiomyopathy |
| title_sort | maternal and fetal outcome of subsequent pregnancy in patients with documented peripartum cardiomyopathy |
| topic | Peripartum Cardiomyopathy |
| url | http://hdl.handle.net/11427/29669 |
| work_keys_str_mv | AT masukudavidsifiso maternalandfetaloutcomeofsubsequentpregnancyinpatientswithdocumentedperipartumcardiomyopathy |