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Primary cutaneous malignancies in the Northern Cape Province of South Africa: A retrospective histopathological review
Background: Excessive sun exposure and high human immunodeficiency virus prevalence increase skin cancer risk in South Africa. Objective: To describe the nature and extent of skin cancers presenting in public and private health sectors of the Northern Cape Province. Methods: A retrospective analysis...
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Division of Dermatology
2019
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| _version_ | 1867614383380627456 |
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| access_status_str | Open Access |
| author | York, Katherine |
| author2 | Khumalo, Nonhlanhla P |
| author_browse | Khumalo, Nonhlanhla P York, Katherine |
| author_facet | Khumalo, Nonhlanhla P York, Katherine |
| author_sort | York, Katherine |
| collection | Thesis |
| description | Background: Excessive sun exposure and high human immunodeficiency virus prevalence increase skin cancer risk in South Africa. Objective: To describe the nature and extent of skin cancers presenting in public and private health sectors of the Northern Cape Province. Methods: A retrospective analysis of histologically-confirmed new primary cutaneous malignancies from 1/1/2008 to 31/12/2012 was conducted using public and private health sector databases. Types, quantity and distribution of common invasive malignancies by population group, age, gender, anatomical site and health sector were explored. One-year cumulative incidence was calculated and logistic regression models were used to analyse incidence and melanoma thickness trends. Results: 4270 biopsies (14 cutaneous malignancies) were identified. Most common were Squamous Cell Carcinoma (SCC), Basal Cell Carcinoma (BCC), Kaposi Sarcoma (KS), Cutaneous Malignant Melanoma (CMM) and Basosquamous carcinoma. The odds of a White male developing SCC increased by 8% each year (OR: 1.08; CI: 1.01-1.15; p-value: 0.022) whilst the odds of a Black male developing SCC and KS decreased by 9% (OR: 0.91; CI: 0.84-0.99; p-value: 0.033) and 18% (OR: 0.82; CI: 0.70-0.97; p-value: 0.022) each year, respectively. SCC and CMM were diagnosed at more advanced stages within public versus private sectors. CMM is being detected earlier, as indicated by low stage depth increasing by 72% annually (OR: 1.72; 95% CI: 1.04-3.01; p-value: 0.042). Conclusion: Results suggest that reported skin cancer patterns are changing. There is a need for further research and equitable appropriation of financial resources and effort toward developing primary skin cancer prevention initiatives in South Africa. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/29671 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:51:10.381Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Division of Dermatology |
| publisherStr | Division of Dermatology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/29671 Primary cutaneous malignancies in the Northern Cape Province of South Africa: A retrospective histopathological review York, Katherine Khumalo, Nonhlanhla P Dlova, Ncoza Mosam, Anisa Dermatology Background: Excessive sun exposure and high human immunodeficiency virus prevalence increase skin cancer risk in South Africa. Objective: To describe the nature and extent of skin cancers presenting in public and private health sectors of the Northern Cape Province. Methods: A retrospective analysis of histologically-confirmed new primary cutaneous malignancies from 1/1/2008 to 31/12/2012 was conducted using public and private health sector databases. Types, quantity and distribution of common invasive malignancies by population group, age, gender, anatomical site and health sector were explored. One-year cumulative incidence was calculated and logistic regression models were used to analyse incidence and melanoma thickness trends. Results: 4270 biopsies (14 cutaneous malignancies) were identified. Most common were Squamous Cell Carcinoma (SCC), Basal Cell Carcinoma (BCC), Kaposi Sarcoma (KS), Cutaneous Malignant Melanoma (CMM) and Basosquamous carcinoma. The odds of a White male developing SCC increased by 8% each year (OR: 1.08; CI: 1.01-1.15; p-value: 0.022) whilst the odds of a Black male developing SCC and KS decreased by 9% (OR: 0.91; CI: 0.84-0.99; p-value: 0.033) and 18% (OR: 0.82; CI: 0.70-0.97; p-value: 0.022) each year, respectively. SCC and CMM were diagnosed at more advanced stages within public versus private sectors. CMM is being detected earlier, as indicated by low stage depth increasing by 72% annually (OR: 1.72; 95% CI: 1.04-3.01; p-value: 0.042). Conclusion: Results suggest that reported skin cancer patterns are changing. There is a need for further research and equitable appropriation of financial resources and effort toward developing primary skin cancer prevention initiatives in South Africa. 2019-02-19T13:10:29Z 2019-02-19T13:10:29Z 2018 2019-02-19T11:12:37Z Master Thesis Masters MMed http://hdl.handle.net/11427/29671 eng application/pdf Division of Dermatology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Dermatology York, Katherine Primary cutaneous malignancies in the Northern Cape Province of South Africa: A retrospective histopathological review |
| thesis_degree_str | Master's |
| title | Primary cutaneous malignancies in the Northern Cape Province of South Africa: A retrospective histopathological review |
| title_full | Primary cutaneous malignancies in the Northern Cape Province of South Africa: A retrospective histopathological review |
| title_fullStr | Primary cutaneous malignancies in the Northern Cape Province of South Africa: A retrospective histopathological review |
| title_full_unstemmed | Primary cutaneous malignancies in the Northern Cape Province of South Africa: A retrospective histopathological review |
| title_short | Primary cutaneous malignancies in the Northern Cape Province of South Africa: A retrospective histopathological review |
| title_sort | primary cutaneous malignancies in the northern cape province of south africa a retrospective histopathological review |
| topic | Dermatology |
| url | http://hdl.handle.net/11427/29671 |
| work_keys_str_mv | AT yorkkatherine primarycutaneousmalignanciesinthenortherncapeprovinceofsouthafricaaretrospectivehistopathologicalreview |