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Corpus callosum morphology in children on mid-sagittal MR imaging
Background: There is little published research on the wide variation of corpus callosum (CC) morphology in children, the assessment of which is made difficult by the complex alteration of its appearance in childhood. Objective: The purpose of our study was to assess the morphology of the CC on mid-s...
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| Format: | Thesis |
| Language: | English |
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Division of Radiology
2019
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| _version_ | 1867613344218742785 |
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| access_status_str | Open Access |
| author | Raubenheimer, Lauren |
| author2 | Andronikou, Savvas |
| author_browse | Andronikou, Savvas Raubenheimer, Lauren |
| author_facet | Andronikou, Savvas Raubenheimer, Lauren |
| author_sort | Raubenheimer, Lauren |
| collection | Thesis |
| description | Background: There is little published research on the wide variation of corpus callosum (CC) morphology in children, the assessment of which is made difficult by the complex alteration of its appearance in childhood. Objective: The purpose of our study was to assess the morphology of the CC on mid-sagittal T1- weighted magnetic resonance imaging (MRI) in a large number of children and correlate the findings with demographic and clinical criteria. Materials and methods: We reviewed all brain mid-sagittal T1-weighted MRI’s performed from July to December 2015 and obtained relevant demographic and clinical information from the accompanying report and laboratory system. The CC morphology was analysed by three radiologists and compared using cross tabulation with the chi-square test and ANOVA. Interobserver correlation was assessed using Kappa coefficient of conformance. Results: 257 patients with mean age 72±60 months were included, 142 were male (55%). In abnormal MRI’s the CC was less likely to have an identifiable isthmus and was more likely to be convex, thin and have separation of the fornix insertion (all p<0.01). In young children (< 5 years) the CC was also less likely to have an identifiable isthmus (p=0.01) and was more likely to be convex (p=0.04) but the fornix was more likely to insert normally (p<0.01). Children with tuberous sclerosis had significantly thinner splenia (p=0.02). Conclusion: There is a distinct pathological appearance of the CC. The immature appearance of the corpus callosum can mirror this but is distinguished by normal insertion of the fornix and normal quantitative measurements. Splenial thinning in children with tuberous sclerosis warrants further investigation. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/29692 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:39.078Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Division of Radiology |
| publisherStr | Division of Radiology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/29692 Corpus callosum morphology in children on mid-sagittal MR imaging Raubenheimer, Lauren Andronikou, Savvas Kilborn,Tracy Diagnostic Radiology Background: There is little published research on the wide variation of corpus callosum (CC) morphology in children, the assessment of which is made difficult by the complex alteration of its appearance in childhood. Objective: The purpose of our study was to assess the morphology of the CC on mid-sagittal T1- weighted magnetic resonance imaging (MRI) in a large number of children and correlate the findings with demographic and clinical criteria. Materials and methods: We reviewed all brain mid-sagittal T1-weighted MRI’s performed from July to December 2015 and obtained relevant demographic and clinical information from the accompanying report and laboratory system. The CC morphology was analysed by three radiologists and compared using cross tabulation with the chi-square test and ANOVA. Interobserver correlation was assessed using Kappa coefficient of conformance. Results: 257 patients with mean age 72±60 months were included, 142 were male (55%). In abnormal MRI’s the CC was less likely to have an identifiable isthmus and was more likely to be convex, thin and have separation of the fornix insertion (all p<0.01). In young children (< 5 years) the CC was also less likely to have an identifiable isthmus (p=0.01) and was more likely to be convex (p=0.04) but the fornix was more likely to insert normally (p<0.01). Children with tuberous sclerosis had significantly thinner splenia (p=0.02). Conclusion: There is a distinct pathological appearance of the CC. The immature appearance of the corpus callosum can mirror this but is distinguished by normal insertion of the fornix and normal quantitative measurements. Splenial thinning in children with tuberous sclerosis warrants further investigation. 2019-02-19T13:45:26Z 2019-02-19T13:45:26Z 2018 2019-02-19T10:25:46Z Master Thesis Masters MMed http://hdl.handle.net/11427/29692 eng application/pdf Division of Radiology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Diagnostic Radiology Raubenheimer, Lauren Corpus callosum morphology in children on mid-sagittal MR imaging |
| thesis_degree_str | Master's |
| title | Corpus callosum morphology in children on mid-sagittal MR imaging |
| title_full | Corpus callosum morphology in children on mid-sagittal MR imaging |
| title_fullStr | Corpus callosum morphology in children on mid-sagittal MR imaging |
| title_full_unstemmed | Corpus callosum morphology in children on mid-sagittal MR imaging |
| title_short | Corpus callosum morphology in children on mid-sagittal MR imaging |
| title_sort | corpus callosum morphology in children on mid sagittal mr imaging |
| topic | Diagnostic Radiology |
| url | http://hdl.handle.net/11427/29692 |
| work_keys_str_mv | AT raubenheimerlauren corpuscallosummorphologyinchildrenonmidsagittalmrimaging |