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Corneal epithelial debridement for the treatment of painful bullous keratopathy: A pilot study
Purpose: The aim of the study was to evaluate the outcomes of corneal manual epithelial debridement (MED) for the treatment of painful bullous keratopathy (BK). Methods: In a prospective interventional case series, 15 eyes of 15 consecutive patients presenting with painful BK of varying aetiology...
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| Format: | Thesis |
| Language: | English |
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Division of Ophthalmology
2019
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| _version_ | 1867613266879971328 |
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| access_status_str | Open Access |
| author | McClunan, Daemon |
| author2 | Du Toit, N |
| author_browse | Du Toit, N McClunan, Daemon |
| author_facet | Du Toit, N McClunan, Daemon |
| author_sort | McClunan, Daemon |
| collection | Thesis |
| description | Purpose: The aim of the study was to evaluate the outcomes of corneal manual epithelial debridement (MED) for the treatment of painful bullous keratopathy (BK).
Methods: In a prospective interventional case series, 15 eyes of 15 consecutive patients presenting with painful BK of varying aetiology underwent MED. Patients were followed up at 10 days, 1 month, 2 months, 3 months and 6 months post procedure. Outcome parameters evaluated include numeric rating pain score (NRS), visual acuity (VA), corneal transparency and size of corneal bullae.
Results: The mean NRS was significantly decreased from its baseline value of 7.2 +- 1.7 at all follow-up visits (p < 0.02). Mean VA and corneal transparency remained stable for the duration of the study. In most patients the average size of corneal bullae was initially reduced, but returned to baseline by the end of the study.
Conclusion: MED reduces mean pain scores and temporarily reduces the size of corneal bullae in BK. MED may be considered as a simple, low cost alternative for reducing pain in patients awaiting corneal transplant. Further studies are required to evaluate MED for the treatment of BK and compare outcomes against other palliative treatment options. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/29827 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:25.185Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Division of Ophthalmology |
| publisherStr | Division of Ophthalmology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/29827 Corneal epithelial debridement for the treatment of painful bullous keratopathy: A pilot study McClunan, Daemon Du Toit, N Ophthalmology Bullous keratopathy Corneal epithelial debridement Purpose: The aim of the study was to evaluate the outcomes of corneal manual epithelial debridement (MED) for the treatment of painful bullous keratopathy (BK). Methods: In a prospective interventional case series, 15 eyes of 15 consecutive patients presenting with painful BK of varying aetiology underwent MED. Patients were followed up at 10 days, 1 month, 2 months, 3 months and 6 months post procedure. Outcome parameters evaluated include numeric rating pain score (NRS), visual acuity (VA), corneal transparency and size of corneal bullae. Results: The mean NRS was significantly decreased from its baseline value of 7.2 +- 1.7 at all follow-up visits (p < 0.02). Mean VA and corneal transparency remained stable for the duration of the study. In most patients the average size of corneal bullae was initially reduced, but returned to baseline by the end of the study. Conclusion: MED reduces mean pain scores and temporarily reduces the size of corneal bullae in BK. MED may be considered as a simple, low cost alternative for reducing pain in patients awaiting corneal transplant. Further studies are required to evaluate MED for the treatment of BK and compare outcomes against other palliative treatment options. 2019-02-27T14:26:05Z 2019-02-27T14:26:05Z 2018 2019-02-25T12:13:36Z Master Thesis Masters MMed http://hdl.handle.net/11427/29827 eng application/pdf Division of Ophthalmology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Ophthalmology Bullous keratopathy Corneal epithelial debridement McClunan, Daemon Corneal epithelial debridement for the treatment of painful bullous keratopathy: A pilot study |
| thesis_degree_str | Master's |
| title | Corneal epithelial debridement for the treatment of painful bullous keratopathy: A pilot study |
| title_full | Corneal epithelial debridement for the treatment of painful bullous keratopathy: A pilot study |
| title_fullStr | Corneal epithelial debridement for the treatment of painful bullous keratopathy: A pilot study |
| title_full_unstemmed | Corneal epithelial debridement for the treatment of painful bullous keratopathy: A pilot study |
| title_short | Corneal epithelial debridement for the treatment of painful bullous keratopathy: A pilot study |
| title_sort | corneal epithelial debridement for the treatment of painful bullous keratopathy a pilot study |
| topic | Ophthalmology Bullous keratopathy Corneal epithelial debridement |
| url | http://hdl.handle.net/11427/29827 |
| work_keys_str_mv | AT mcclunandaemon cornealepithelialdebridementforthetreatmentofpainfulbullouskeratopathyapilotstudy |