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Molecular and Kinetic Characterisation of wild type and mutant Porphobilinogen Deaminase

The purpose of this dissertation was to provide an overview of acute intermittent porphyria, focussing on the structure and function of the enzyme, porphobilinogen deaminase (PBGD), as well as experimentally demonstrating the use of kinetic, structural and thermodynamic approaches to shed light o...

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Bibliographic Details
Main Author: Pienaar, Elaine
Other Authors: Meissner, Peter
Format: Thesis
Language:English
Published: Department of Integrative Biomedical Sciences 2019
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